NFL Injury
Team Injury
| Team | Player | Pos | Injury | Status |
|---|---|---|---|---|
| ARI | Dadrion Taylor-Demerson | SAF | Back | Inactive for Week 4 at N.Y. Giants |
| ARI | Josh Fryar | OT | Coach's Decision | — |
| ARI | Reggie Virgil | WR | Coach's Decision | Inactive for Week 4 at N.Y. Giants |
| ARI | Carson Beck | QB | Coach's Decision | Inactive for Week 4 at N.Y. Giants |
| ARI | S. Thomas V | CB | Coach's Decision | — |
| BAL | Jovaughn Gwyn | C | Ankle | IR. Injured Reserve. Expected Return - Week 14 |
| BUF | Skyler Bell | WR | Coach's Decision | Inactive for Week 4 vs. New England |
| BUF | Christian Benford | CB | Toe | Inactive for Week 4 vs. New England |
| BUF | Jude Bowry | OT | Coach's Decision | Inactive for Week 4 vs. New England |
| CHI | Caleb Williams | QB | Hamstring | Inactive for Week 4 vs. N.Y. Jets |
| CHI | Ozzy Trapilo | OT | Coach's Decision | — |
| CHI | James Lynch | DT | Coach's Decision | — |
| CHI | Cam Lewis | CB | Hip | Inactive for Week 4 vs. N.Y. Jets |
| CHI | Jayden Loving | DT | Coach's Decision | — |
| CHI | Jamree Kromah | DE | Coach's Decision | — |
| CIN | Swayze Bozeman | LB | Groin | Inactive for Week 4 vs. Jacksonville |
| DAL | Camden Brown | WR | Coach's Decision | Inactive for Week 4 at Houston |
| GB | Jacob Monk | G | Quadriceps | Inactive for Week 4 at Tampa Bay |
| GB | Anthony Campbell | DT | Ankle | Inactive for Week 4 at Tampa Bay |
| GB | Aaron Banks | G | Toe | Inactive for Week 4 at Tampa Bay |
| HOU | Azeez Al-Shaair | LB | Groin | Inactive for Week 4 vs. Dallas |
| IND | Darius Slayton | WR | Coach's Decision | Inactive for Week 4 at Washington |
| IND | Keenan Allen | WR | Groin | Inactive for Week 4 at Washington |
| IND | Riley Leonard | QB | Coach's Decision | Inactive for Week 4 at Washington |
| IND | G. Gumbs Jr. | DE | Coach's Decision | Inactive for Week 4 at Washington |
| IND | DJ Giddens | RB | Coach's Decision | Inactive for Week 4 at Washington |
| IND | Dalton Tucker | G | Coach's Decision | Inactive for Week 4 at Washington |
| JAC | Jack Kiser | LB | Coach's Decision | — |
| JAC | Daniel Faalele | G | Coach's Decision | — |
| JAC | Montaric Brown | CB | Hamstring | Inactive for Week 4 at Cincinnati |
| JAC | Jalen Huskey | SAF | Coach's Decision | — |
| JAC | CJ Williams | WR | Coach's Decision | — |
| JAC | Wesley Williams | DE | Coach's Decision | — |
| JAC | Christian Braswell | CB | Knee | Inactive for Week 4 at Cincinnati |
| LAR | Josaiah Stewart | LB | Groin | Questionable for Week 4 at Philadelphia |
| LV | Jackson Powers-Johnson | G | Groin | Out for Week 4 vs. Kansas City. Expected Return - Week 5 |
| NE | Christian Barmore | DT | Shoulder | Inactive for Week 4 at Buffalo |
| NE | Channing Canada | CB | Hamstring | Inactive for Week 4 at Buffalo |
| NE | Tanner Arkin | TE | Coach's Decision | Inactive for Week 4 at Buffalo |
| NO | Pete Werner | LB | Shoulder | Did Not Practice on Saturday. Questionable for Week 4 vs. Atlanta |
| PHI | Zack Baun | LB | Concussion | Inactive for Week 4 vs. L.A. Rams |
| PHI | Marquise Brown | WR | Ankle | Inactive for Week 4 vs. L.A. Rams |
| PHI | Lane Johnson | OT | Personal | Questionable for Week 4 vs. L.A. Rams |
| PIT | Derrick Harmon | DT | Foot | Doubtful for Week 5 vs. Indianapolis |
| PIT | Jamel Dean | CB | Ankle | Doubtful for Week 5 vs. Indianapolis |
| TB | Jacob Parrish | CB | Personal | Limited Practice on Friday. Questionable for Week 4 vs. Green Bay |
| TB | R. Bain Jr. | LB | Groin | Inactive for Week 4 vs. Green Bay |
| TB | DeMonte Capehart | DT | Coach's Decision | — |
| TEN | Jackie Marshall | DT | Coach's Decision | — |
| TEN | Brandon Crenshaw-Dickson | OT | Coach's Decision | — |
| TEN | Kylen Granson | TE | Coach's Decision | — |
| TEN | Michael Carter | RB | Coach's Decision | — |
| TEN | Jaylon Jones | DB | Coach's Decision | — |
| WAS | Samuel Cosmi | OT | Concussion | Inactive for Week 4 vs. Indianapolis |
| WAS | Luke McCaffrey | WR | Coach's Decision | Inactive for Week 4 vs. Indianapolis |
| WAS | Terry McLaurin | WR | Hamstring | Inactive for Week 4 vs. Indianapolis |
| WAS | Charles Omenihu | DE | Groin | Questionable for Week 5 vs. N.Y. Giants |
| WAS | Rachaad White | RB | Shoulder | Inactive for Week 4 vs. Indianapolis |
| WAS | Javontae Jean-Baptiste | LB | Coach's Decision | Inactive for Week 4 vs. Indianapolis |
| WAS | Nick Cross | SAF | Illness | Inactive for Week 4 vs. Indianapolis |
| WAS | Jaylin Lane | WR | Leg | Questionable for Week 5 vs. N.Y. Giants |
| WAS | Jayden Daniels | QB | Elbow | Inactive for Week 4 vs. Indianapolis |
| WAS | Marcus Mariota | QB | Knee | Out for Week 5 vs. N.Y. Giants. Expected Return - Week 5 |
| BAL | Ethan Pocic | C | Knee | IR. Injured Reserve. Expected Return - Week 8 |
| CAR | Cam Jackson | DT | Knee | Limited Practice on Friday. Questionable for Week 4 vs. Detroit |
| CAR | Xavier Legette | WR | Knee | IR. Injured Reserve. Expected Return - Week 9 |
| CHI | Braxton Jones | OT | Knee | IR. Injured Reserve. Expected Return - Week 8 |
| GB | Warren Brinson | DT | Calf | IR. Injured Reserve. Expected Return - Week 8 |
| HOU | Jake Hansen | LB | Knee | Full Practice on Friday. Questionable for Week 4 vs. Dallas |
| LAR | Aaron Donald | DT | Back | Out for Week 4 at Philadelphia. Expected Return - Week 5 |
| NO | Carl Granderson | DE | Ankle | Out for Week 4 vs. Atlanta. Expected Return - Week 5 |
| NO | Anfernee Jennings | LB | Knee | Out for Week 4 vs. Atlanta. Expected Return - Week 5 |
| NO | Jordyn Tyson | WR | Hamstring | IR. Injured Reserve. Expected Return - Week 5 |
| NO | Kaden Elliss | LB | Calf | Out for Week 4 vs. Atlanta. Expected Return - Week 5 |
| SEA | Jadarian Price | RB | Chest | IR. Injured Reserve. Expected Return - Week 8 |
| TEN | Garrett Dellinger | G | Illness | Questionable for Week 4 at Baltimore |
| ARI | Will Johnson | CB | Neck | IR. Injured Reserve |
| ARI | Chase Bisontis | OT | Knee - MCL | IR. Injured Reserve |
| ARI | Josh Minkins | DB | Undisclosed | Questionable for Week 4 at N.Y. Giants |
| ARI | Andre Baccellia | WR | Neck | Questionable for Week 4 at N.Y. Giants |
| ARI | Tip Reiman | TE | Ankle | Physically Unable to Perform. Expected Return - Week 5 |
| ARI | Kitan Crawford | SAF | Ankle | IR. Injured Reserve. Expected Return - Week 6 |
| ARI | Jameson Geers | TE | Undisclosed | IR. Injured Reserve |
| ARI | JJ Russell | ILB | Concussion | Questionable for Week 4 at N.Y. Giants |
| ARI | Trey Benson | RB | Knee | IR. Injured Reserve |
| ARI | Zachary Carter | DT | Knee | IR. Injured Reserve. Expected Return - Week 5 |
| ARI | Kenny Yeboah | TE | Hamstring | Questionable for Week 4 at N.Y. Giants |
| ARI | Jonah Williams | OT | Shoulder | Questionable for Week 4 at N.Y. Giants |
| ARI | James Conner | RB | Foot | IR. Injured Reserve. Expected Return - Week 5 |
| ARI | Xavier Weaver | WR | Hamstring | Questionable for Week 4 at N.Y. Giants |
| ARI | Kaleb Proctor | DT | Knee - Meniscus | IR. Injured Reserve |
| ARI | Bilal Nichols | DT | Knee | Questionable for Week 4 at N.Y. Giants |
| ARI | Justin Jones | DT | Knee | Questionable for Week 4 at N.Y. Giants |
| ATL | Kaleb McGary | OT | Leg | Retired |
| ATL | Divine Deablo | LB | Hamstring | Limited Practice on Saturday. Questionable for Week 4 at New Orleans |
| ATL | A.J. Terrell | CB | Groin | IR. Injured Reserve. Expected Return - Week 7 |
| ATL | Troy Andersen | LB | Knee | Questionable for Week 4 at New Orleans |
| ATL | Da'Shawn Hand | DE | Quadriceps | IR. Injured Reserve |
| ATL | Malik Verdon | LB | Undisclosed | Questionable for Week 4 at New Orleans |
| ATL | T. Wheatley Jr. | OT | Undisclosed | Questionable for Week 4 at New Orleans |
| ATL | DeAngelo Malone | LB | Undisclosed | Physically Unable to Perform |
| ATL | Beaux Collins | WR | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| ATL | Trey Sermon | RB | Undisclosed | IR. Injured Reserve |
| ATL | Jalon Walker | LB | Knee - ACL | IR. Injured Reserve |
| ATL | Anterio Thompson | DT | Undisclosed | NFI-R for Week 4 at New Orleans |
| ATL | JD Bertrand | LB | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| ATL | Le'Meke Brockington | WR | Undisclosed | Questionable for Week 4 at New Orleans |
| ATL | Cameron Williams | OT | Ankle | IR. Injured Reserve. Expected Return - Week 5 |
| ATL | Samson Ebukam | DE | Hamstring | Full Practice on Saturday. Questionable for Week 4 at New Orleans |
| ATL | Storm Norton | OT | Foot | Physically Unable to Perform |
| ATL | Kevin King | CB | Undisclosed | Questionable for Week 4 at New Orleans |
| ATL | Jamal Agnew | WR | Undisclosed | Questionable for Week 4 at New Orleans |
| BAL | Trey Hendrickson | LB | Finger | Out for Week 4 vs. Tennessee. Expected Return - Week 5 |
| BAL | Adam Randall | RB | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| BAL | Reid Williford | LB | Undisclosed | Questionable for Week 4 vs. Tennessee |
| BAL | Bilhal Kone | CB | Lower Body | IR. Injured Reserve. Expected Return - Week 5 |
| BAL | Ja'Kobi Lane | WR | Wrist | IR. Injured Reserve. Expected Return - Week 6 |
| BAL | Deonte Harty | WR | Knee | Questionable for Week 4 vs. Tennessee |
| BAL | T.J. Tampa | CB | Knee | IR. Injured Reserve. Expected Return - Week 6 |
| BAL | Danny Pinter | G | Knee | IR. Injured Reserve |
| BAL | Kendall Lamm | OT | Undisclosed | Retired |
| BAL | Jahquez Robinson | SAF | Undisclosed | IR. Injured Reserve |
| BAL | Chris Moore | WR | Ankle | Limited Practice on Friday. Questionable for Week 4 vs. Tennessee |
| BAL | Skylar Thompson | QB | Undisclosed | IR. Injured Reserve |
| BAL | Ronnie Stanley | OT | Toe | Did Not Practice on Friday. Questionable for Week 4 vs. Tennessee |
| BUF | Dorian Strong | CB | Neck | NFI-R for Week 4 vs. New England |
| BUF | Tyrell Shavers | WR | Knee - ACL | Physically Unable to Perform. Expected Return - Week 5 |
| BUF | Jordan Poyer | FS | Hamstring | Questionable for Week 4 vs. New England |
| BUF | Jordan Hancock | CB | Hamstring | IR. Injured Reserve. Expected Return - Week 8 |
| BUF | Jalen Virgil | WR | Undisclosed | Questionable for Week 4 vs. New England |
| BUF | Zane Durant | DT | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| BUF | T.J. Sanders | DT | Appendix | Limited Practice on Friday. Doubtful for Week 4 vs. New England |
| BUF | Demetrius Flannigan-Fowles | LB | Undisclosed | Questionable for Week 4 vs. New England |
| BUF | Ray Davis | RB | Hamstring | Limited Practice on Friday. Questionable for Week 4 vs. New England |
| BUF | Jordan Phillips | DT | Ankle | Questionable for Week 4 vs. New England |
| BUF | BoseGrant DuBose | WR | Shoulder | Questionable for Week 4 vs. New England |
| CAR | Damien Lewis | G | Elbow | Out for Week 4 vs. Detroit. Expected Return - Week 6 |
| CAR | Trevor Etienne | RB | Ankle | IR. Injured Reserve. Expected Return - Week 6 |
| CAR | C. Brazzell II | WR | Knee | IR. Injured Reserve |
| CAR | Brady Christensen | OT | Hamstring | IR. Injured Reserve. Expected Return - Week 6 |
| CAR | Mike Jackson | CB | Groin | IR. Injured Reserve. Expected Return - Week 11 |
| CAR | Taylor Moton | OT | Illness | NFI-R for Week 4 vs. Detroit |
| CAR | Amare Barno | LB | Knee | Questionable for Week 4 vs. Detroit |
| CAR | Jalen Coker | WR | Quadriceps | Limited Practice on Friday. Questionable for Week 4 vs. Detroit |
| CAR | Ainias Smith | WR | Undisclosed | Questionable for Week 4 vs. Detroit |
| CAR | LaBryan Ray | DT | Personal | Retired |
| CAR | Josey Jewell | ILB | Concussion | Questionable for Week 4 vs. Detroit |
| CAR | Ryan Hayes | OT | Undisclosed | Questionable for Week 4 vs. Detroit |
| CAR | Will Grier | QB | Personal | Retired |
| CAR | Lee Hunter | DT | Foot | Limited Practice on Friday. Questionable for Week 4 vs. Detroit |
| CAR | Jaycee Horn | CB | Quadriceps | IR. Injured Reserve. Expected Return - Week 10 |
| CAR | Jonathon Brooks | RB | Abdomen | IR. Injured Reserve. Expected Return - Week 9 |
| CAR | Ikem Ekwonu | OT | Knee | Physically Unable to Perform. Expected Return - Week 6 |
| CAR | Bam Martin-Scott | LB | Hamstring | IR. Injured Reserve. Expected Return - Week 6 |
| CAR | Tyler Mabry | TE | Undisclosed | Questionable for Week 4 vs. Detroit |
| CAR | Dan Chisena | WR | Undisclosed | Questionable for Week 4 vs. Detroit |
| CAR | Tershawn Wharton | DE | Neck | Physically Unable to Perform. Expected Return - Week 6 |
| CAR | Claudin Cherelus | LB | Shoulder | Questionable for Week 4 vs. Detroit |
| CAR | Nic Scourton | LB | Knee - ACL | IR. Injured Reserve |
| CHI | Kyron Hudson | WR | Undisclosed | Questionable for Week 4 vs. N.Y. Jets |
| CHI | Nikola Kalinic | TE | Knee | IR. Injured Reserve |
| CHI | Dallis Flowers | CB | Leg | IR. Injured Reserve |
| CHI | Kyler Gordon | CB | Calf | Physically Unable to Perform. Expected Return - Week 5 |
| CHI | Drew Dalman | C | Undisclosed | Retired |
| CHI | Jonathan Garvin | DE | Undisclosed | IR. Injured Reserve |
| CHI | Hayden Large | TE | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| CHI | Dontae Manning | CB | Undisclosed | Questionable for Week 4 vs. N.Y. Jets |
| CHI | Nephi Sewell | LB | Concussion | IR. Injured Reserve |
| CHI | Brittain Brown | RB | Undisclosed | IR. Injured Reserve |
| CHI | Ray-Ray McCloud | WR | Undisclosed | Questionable for Week 4 vs. N.Y. Jets |
| CHI | A. Johnson Jr. | SAF | Undisclosed | Out for Week 4 vs. N.Y. Jets. Expected Return - Week 6 |
| CHI | Shemar Turner | DT | Knee - ACL | Physically Unable to Perform. Expected Return - Week 5 |
| CHI | Ty Summers | LB | Foot | Questionable for Week 4 vs. N.Y. Jets |
| CHI | Jaylon Jones | DB | Hamstring | Questionable for Week 4 vs. N.Y. Jets |
| CHI | Ricky Stromberg | OL | Undisclosed | Questionable for Week 4 vs. N.Y. Jets |
| CHI | Gervarrius Owens | SAF | Undisclosed | Questionable for Week 4 vs. N.Y. Jets |
| CHI | Noah Sewell | LB | Achilles | Physically Unable to Perform. Expected Return - Week 5 |
| CHI | R. Hyppolite II | LB | Shoulder | IR. Injured Reserve |
| CHI | T. Fields II | LB | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| CHI | Anthony Johnson | CB | Undisclosed | IR. Injured Reserve. Expected Return - Week 6 |
| CHI | KC Eziomume | DB | Undisclosed | Questionable for Week 4 vs. N.Y. Jets |
| CHI | Coby Bryant | CB | Knee | IR. Injured Reserve. Expected Return - Week 15 |
| CIN | Bryan Cook | SAF | Ankle | Limited Practice on Friday. Questionable for Week 4 vs. Jacksonville |
| CIN | Zack Moss | RB | Neck | Questionable for Week 4 vs. Jacksonville |
| CIN | B. Parker II | OT | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| CIN | Ja'Sir Taylor | CB | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| CIN | Jalen Davis | CB | Hamstring | IR. Injured Reserve. Expected Return - Week 9 |
| CIN | Dalton Risner | G | Knee | Full Practice on Friday. Questionable for Week 4 vs. Jacksonville |
| CIN | Andrei Iosivas | WR | Thumb | IR. Injured Reserve. Expected Return - Week 8 |
| CIN | B.J. Hill | DT | Achilles | Limited Practice on Friday. Questionable for Week 4 vs. Jacksonville |
| CIN | Jaxson Kirkland | OG | Undisclosed | Questionable for Week 4 vs. Jacksonville |
| CIN | Colbie Young | WR | Knee | Out for Week 4 vs. Jacksonville. Expected Return - Week 5 |
| CIN | Kyle Dugger | SAF | Quadriceps | Out for Week 4 vs. Jacksonville. Expected Return - Week 5 |
| CLE | Jamari Thrash | WR | Undisclosed | Questionable for Week 5 at N.Y. Jets |
| CLE | Tyron Herring | SAF | Undisclosed | Questionable for Week 5 at N.Y. Jets |
| CLE | Damarri Mathis | DB | Undisclosed | IR. Injured Reserve |
| CLE | Jeremiah Owusu-Koramoah | LB | Neck | Physically Unable to Perform |
| CLE | Nathaniel Watson | LB | Knee | Out for Week 5 at N.Y. Jets. Expected Return - Week 7 |
| CLE | Markees Watts | LB | Undisclosed | Retired |
| CLE | Dylan Sampson | RB | Knee | IR. Injured Reserve. Expected Return - Week 6 |
| CLE | Mason Graham | DT | Knee | Questionable for Week 5 at N.Y. Jets |
| CLE | Edefuan Ulofoshio | LB | Biceps | IR. Injured Reserve |
| CLE | Travis Bell | DT | Eye | Questionable for Week 5 at N.Y. Jets |
| CLE | Teven Jenkins | G | Back | Inactive for Week 4 vs. Pittsburgh |
| CLE | Alex Wright | DE | Achilles | IR. Injured Reserve |
| CLE | Elijah Chatman | DT | Quadriceps | IR. Injured Reserve |
| CLE | Aaron Anderson | WR | Undisclosed | Questionable for Week 5 at N.Y. Jets |
| CLE | Kalia Davis | DT | Quadriceps | IR. Injured Reserve. Expected Return - Week 5 |
| CLE | Dom Jones | CB | Knee | Questionable for Week 5 at N.Y. Jets |
| CLE | Tyreak Sapp | DE | Undisclosed | Questionable for Week 5 at N.Y. Jets |
| CLE | Dillon Gabriel | QB | Back | IR. Injured Reserve. Expected Return - Week 5 |
| CLE | Joe Royer | TE | Personal | NFI-R for Week 5 at N.Y. Jets |
| DAL | Devin Moore | CB | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| DAL | Matt Hennessy | C | Neck | IR. Injured Reserve |
| DAL | Jalen Thompson | DB | Hamstring | IR. Injured Reserve. Expected Return - Week 8 |
| DAL | Malik Davis | RB | Hip | IR. Injured Reserve |
| DAL | P.J. Locke | DB | Foot | IR. Injured Reserve. Expected Return - Week 7 |
| DAL | Marist Liufau | LB | Forearm | IR. Injured Reserve. Expected Return - Week 5 |
| DAL | Jonathan Bullard | DE | Calf | IR. Injured Reserve. Expected Return - Week 8 |
| DAL | Tyler Smith | G | Thumb | IR. Injured Reserve. Expected Return - Week 5 |
| DAL | DeMarvion Overshown | LB | Hamstring | Out for Week 4 at Houston. Expected Return - Week 6 |
| DAL | Princeton Fant | TE | Knee - ACL + MCL | IR. Injured Reserve |
| DAL | Decobie Durant | CB | Hamstring | Out for Week 4 at Houston. Expected Return - Week 6 |
| DAL | K. Gilliam Jr. | DT | Triceps | IR. Injured Reserve |
| DEN | Jonah Coleman | RB | Ankle | IR. Injured Reserve. Expected Return - Week 7 |
| DEN | Dondrea Tillman | LB | Hamstring | Out for Week 4 at San Francisco. Expected Return - Week 5 |
| DEN | Michael Deiter | C | Quadriceps | IR. Injured Reserve |
| DEN | Caleb Lohner | TE | Lower Body | IR. Injured Reserve. Expected Return - Week 5 |
| DEN | Levelle Bailey | LB | Leg | IR. Injured Reserve |
| DEN | Drew Sanders | LB | Undisclosed | Questionable for Week 4 at San Francisco |
| DEN | Blake Cotton | DB | Hamstring | Questionable for Week 4 at San Francisco |
| DEN | Nick Gargiulo | G | Knee - ACL | Physically Unable to Perform. Expected Return - Week 5 |
| DEN | Frank Crum | OT | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| DEN | M. Woods II | WR | Leg | Questionable for Week 4 at San Francisco |
| DEN | Matt Henningsen | DE | Achilles | IR. Injured Reserve |
| DET | Luke Deal | TE | Undisclosed | Questionable for Week 4 at Carolina |
| DET | Thomas Harper | SAF | Ankle | IR. Injured Reserve. Expected Return - Week 8 |
| DET | De'Shawn Rucker | CB | Ankle | Questionable for Week 4 at Carolina |
| DET | Emmanuel Moseley | DB | Illness | Questionable for Week 4 at Carolina |
| DET | Damone Clark | LB | Undisclosed | IR. Injured Reserve |
| DET | Cade Mays | C | Wrist | IR. Injured Reserve. Expected Return - Week 7 |
| DET | Kye Robichaux | RB | Foot | Questionable for Week 4 at Carolina |
| DET | C. Wilson Jr. | WR | Knee | Questionable for Week 4 at Carolina |
| DET | M. Norris Jr. | SAF | Concussion | Questionable for Week 4 at Carolina |
| DET | Dicaprio Bootle | CB | Undisclosed | Questionable for Week 4 at Carolina |
| DET | Divaad Wilson | CB | Undisclosed | Questionable for Week 4 at Carolina |
| DET | Giovanni Manu | OL | Knee | NFI-R for Week 4 at Carolina |
| DET | Raheem Blackshear | RB | Undisclosed | Questionable for Week 4 at Carolina |
| DET | Isiah Pacheco | RB | Back | IR. Injured Reserve. Expected Return - Week 13 |
| DET | Michael Niese | G | Leg | Questionable for Week 4 at Carolina |
| DET | Avonte Maddox | FS | Foot | IR. Injured Reserve |
| DET | Kerby Joseph | SAF | Knee | Physically Unable to Perform. Expected Return - Week 5 |
| DET | Jamarco Jones | OT | Achilles | Questionable for Week 4 at Carolina |
| DET | Brian Branch | CB | Achilles | Physically Unable to Perform. Expected Return - Week 5 |
| DET | Teddy Bridgewater | QB | Undisclosed | Retired |
| DET | Zach Cunningham | ILB | Hamstring | Questionable for Week 4 at Carolina |
| DET | Aidan Keanaaina | DT | Undisclosed | Questionable for Week 4 at Carolina |
| DET | D.J. Reed | CB | Ribs | Limited Practice on Friday. Questionable for Week 4 at Carolina |
| DET | Kendrick Law | WR | Knee - ACL | IR. Injured Reserve |
| DET | Payton Turner | DE | Back | IR. Injured Reserve |
| DET | Loren Strickland | SAF | Undisclosed | Questionable for Week 4 at Carolina |
| DET | Anthony Firkser | TE | Leg | Questionable for Week 4 at Carolina |
| DET | Ben Bartch | OT | Foot | Out for Week 4 at Carolina. Expected Return - Week 5 |
| GB | K. Randolph Jr. | DT | Undisclosed | Questionable for Week 4 at Tampa Bay |
| GB | T. Dean III | SAF | Undisclosed | Questionable for Week 4 at Tampa Bay |
| GB | McCallan Castles | TE | Undisclosed | Questionable for Week 4 at Tampa Bay |
| GB | Luke Lachey | TE | Foot | Questionable for Week 4 at Tampa Bay |
| GB | Luke Musgrave | TE | Neck | Physically Unable to Perform. Expected Return - Week 5 |
| GB | Zach Bako-Bewele | G | Knee | IR. Injured Reserve |
| GB | P. Strong Jr. | RB | Hamstring | Questionable for Week 4 at Tampa Bay |
| GB | Savion Williams | WR | Ankle | IR. Injured Reserve. Expected Return - Week 5 |
| GB | Johnathan Baldwin | SAF | Knee | IR. Injured Reserve |
| GB | Isaiah Dunn | CB | Undisclosed | Questionable for Week 4 at Tampa Bay |
| GB | Thomas Yassmin | TE | Undisclosed | IR. Injured Reserve |
| GB | Jordon Riley | DT | Achilles | Physically Unable to Perform. Expected Return - Week 5 |
| GB | Micah Parsons | LB | Knee - ACL | Physically Unable to Perform. Expected Return - Week 6 |
| GB | Marlon Jones | DB | Undisclosed | IR. Injured Reserve |
| GB | Jayden Reed | WR | Neck | IR. Injured Reserve |
| GB | Jager Burton | G | Groin | Limited Practice on Friday. Questionable for Week 4 at Tampa Bay |
| GB | RJ Maryland | TE | Hamstring | Questionable for Week 4 at Tampa Bay |
| GB | Collin Oliver | LB | Achilles | IR. Injured Reserve. Expected Return - Week 5 |
| HOU | Irv Smith | TE | Ankle | Questionable for Week 4 vs. Dallas |
| HOU | Casey Toohill | DE | Personal | Retired |
| HOU | Sam Hagen | OT | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| HOU | Graham Mertz | QB | Knee - ACL | IR. Injured Reserve |
| HOU | Jake Hummel | LB | Groin | IR. Injured Reserve. Expected Return - Week 7 |
| HOU | Braden Smith | OT | Foot | IR. Injured Reserve. Expected Return - Week 5 |
| HOU | Joe Mixon | RB | Foot | Out for Week 4 vs. Dallas. Expected Return - Week 4 |
| HOU | Sione Takitaki | LB | Hamstring | Questionable for Week 4 vs. Dallas |
| HOU | Ed Ingram | G | Groin | Full Practice on Friday. Questionable for Week 4 vs. Dallas |
| HOU | Kurt Hinish | DT | Undisclosed | Questionable for Week 4 vs. Dallas |
| HOU | M.J. Stewart | SAF | Knee | Physically Unable to Perform. Expected Return - Week 5 |
| HOU | Jadeveon Clowney | DE | Knee | Did Not Practice on Friday. Questionable for Week 4 vs. Dallas |
| HOU | Jimmie Ward | CB | Foot | Questionable for Week 4 vs. Dallas |
| HOU | Tank Dell | WR | Knee - ACL + MCL | IR. Injured Reserve. Expected Return - Week 5 |
| HOU | Mario Edwards | DT | Knee - ACL | IR. Injured Reserve |
| HOU | Ja'Marcus Ingram | CB | Shoulder | IR. Injured Reserve. Expected Return - Week 5 |
| HOU | Jayden Higgins | WR | Knee - ACL | IR. Injured Reserve |
| HOU | DJ Turner | WR | Undisclosed | Questionable for Week 4 vs. Dallas |
| HOU | Trent Brown | OT | Illness | Full Practice on Friday. Questionable for Week 4 vs. Dallas |
| HOU | Logan Hall | DE | Knee | Limited Practice on Friday. Questionable for Week 4 vs. Dallas |
| HOU | Solomon Byrd | DE | Ankle | IR. Injured Reserve |
| HOU | Ali Gaye | DE | Knee | IR. Injured Reserve |
| HOU | To'oHenry To'oTo'o | LB | Shoulder | IR. Injured Reserve. Expected Return - Week 6 |
| HOU | Kyonte Hamilton | DT | Undisclosed | Questionable for Week 4 vs. Dallas |
| HOU | Kayden McDonald | DT | Ankle | IR. Injured Reserve. Expected Return - Week 5 |
| HOU | Dylan Horton | DE | Achilles | IR. Injured Reserve |
| HOU | British Brooks | RB | Hamstring | IR. Injured Reserve. Expected Return - Week 9 |
| HOU | E.J. Speed | LB | Quadriceps | Physically Unable to Perform |
| HOU | K.C. Ossai | LB | Undisclosed | IR. Injured Reserve |
| HOU | Noah Whittington | RB | Quadriceps | Out for Week 4 vs. Dallas. Expected Return - Week 9 |
| IND | Chris Lammons | DB | Foot | Questionable for Week 5 at Pittsburgh |
| IND | Alec Pierce | WR | Heel | IR. Injured Reserve. Expected Return - Week 7 |
| IND | D.J. Montgomery | WR | Abdomen | IR. Injured Reserve |
| IND | Micheal Clemons | DE | Toe | IR. Injured Reserve. Expected Return - Week 7 |
| IND | Jack Wilson | OT | Undisclosed | Questionable for Week 5 at Pittsburgh |
| IND | R. Lowery III | DB | Undisclosed | Retired |
| IND | Cameron Mitchell | DB | Undisclosed | IR. Injured Reserve |
| IND | Will Mallory | TE | Thumb | IR. Injured Reserve. Expected Return - Week 5 |
| IND | Sean McKeon | TE | Undisclosed | Questionable for Week 5 at Pittsburgh |
| IND | Mike Hilton | CB | Shoulder | Questionable for Week 5 at Pittsburgh |
| IND | Jacob Phillips | LB | Biceps | Questionable for Week 5 at Pittsburgh |
| IND | Carson Towt | TE | Undisclosed | IR. Injured Reserve |
| JAC | Parker Hughes | LB | Undisclosed | IR. Injured Reserve |
| JAC | Keith Taylor | CB | Undisclosed | Questionable for Week 4 at Cincinnati |
| JAC | Devon Marshall | DB | Undisclosed | Questionable for Week 4 at Cincinnati |
| JAC | Patrick Mekari | OT | Back | IR. Injured Reserve. Expected Return - Week 5 |
| JAC | GiorgioGarrett DiGiorgio | OT | Undisclosed | IR. Injured Reserve |
| JAC | Sam Mustipher | C | Undisclosed | IR. Injured Reserve |
| JAC | Zach Durfee | DE | Upper Body | IR. Injured Reserve. Expected Return - Week 5 |
| JAC | Dane Jackson | CB | Personal | Retired |
| JAC | Jared Bartlett | LB | Leg | IR. Injured Reserve |
| JAC | Trystan Colon-Castillo | C | Personal | Retired |
| JAC | B. Green II | DE | Elbow | IR. Injured Reserve. Expected Return - Week 6 |
| JAC | Carter Bradley | QB | Thumb | Questionable for Week 4 at Cincinnati |
| KC | Deon Bush | DB | Achilles | Questionable for Week 4 at Las Vegas |
| KC | Chris Oladokun | QB | Undisclosed | Questionable for Week 4 at Las Vegas |
| KC | Josh Simmons | OT | Back | Out for Week 4 at Las Vegas. Expected Return - Week 6 |
| KC | EJ Smith | RB | Undisclosed | Questionable for Week 4 at Las Vegas |
| KC | Jimmy Holiday | WR | Undisclosed | IR. Injured Reserve |
| KC | Jeff Caldwell | WR | Knee | IR. Injured Reserve |
| KC | John Michael Gyllenborg | TE | Knee | IR. Injured Reserve |
| KC | C.J. Hanson | G | Undisclosed | Questionable for Week 4 at Las Vegas |
| KC | Omarr Norman-Lott | DT | Knee - ACL | Physically Unable to Perform. Expected Return - Week 6 |
| KC | Matt Waletzko | OT | Undisclosed | IR. Injured Reserve |
| KC | Cooper McDonald | LB | Knee | IR. Injured Reserve. Expected Return - Week 7 |
| KC | Ethan Downs | LB | Knee - ACL | IR. Injured Reserve |
| LAC | Dalevon Campbell | WR | Leg | Questionable for Week 4 at Seattle |
| LAC | Sincere Brown | WR | Undisclosed | Questionable for Week 4 at Seattle |
| LAC | Donte Jackson | CB | Concussion | Full Practice on Friday. Questionable for Week 4 at Seattle |
| LAC | Trey Pipkins | OT | Knee | IR. Injured Reserve. Expected Return - Week 8 |
| LAC | Dez Fitzpatrick | WR | Undisclosed | Questionable for Week 4 at Seattle |
| LAC | Dalvin Tomlinson | DE | Hamstring | Out for Week 4 at Seattle. Expected Return - Week 5 |
| LAC | Brenen Thompson | WR | Quadriceps | Out for Week 4 at Seattle. Expected Return - Week 5 |
| LAC | Trey Lance | QB | Groin | Limited Practice on Friday. Questionable for Week 4 at Seattle |
| LAC | Scott Matlock | DT | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| LAC | Kayode Awosika | G | Lower Leg | Out for Week 4 at Seattle. Expected Return - Week 5 |
| LAC | Ladd McConkey | WR | Foot | Limited Practice on Friday. Questionable for Week 4 at Seattle |
| LAC | Denzel Perryman | MLB | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| LAC | Kyle Kennard | LB | Undisclosed | Questionable for Week 4 at Seattle |
| LAC | Mike Williams | WR | Undisclosed | Roster Exemption |
| LAC | Bradley Bozeman | C | Undisclosed | Retired |
| LAC | Charlie Kolar | TE | Forearm | Out for Week 4 at Seattle. Expected Return - Week 5 |
| LAC | David Njoku | TE | Lower Leg | IR. Injured Reserve. Expected Return - Week 8 |
| LAC | Will Dissly | TE | Undisclosed | Questionable for Week 4 at Seattle |
| LAC | Derwin James | FS | Hamstring | Questionable for Week 4 at Seattle |
| LAC | Luke Grimm | WR | Undisclosed | Questionable for Week 4 at Seattle |
| LAC | Branson Taylor | OT | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| LAC | Isaiah World | OT | Knee | NFI-R for Week 4 at Seattle |
| LAC | Elijah Molden | CB | Hamstring | Limited Practice on Friday. Questionable for Week 4 at Seattle |
| LAC | KeAndre Lambert-Smith | WR | Hamstring | IR. Injured Reserve. Expected Return - Week 6 |
| LAR | Zech McPhearson | CB | Undisclosed | Questionable for Week 4 at Philadelphia |
| LAR | Colby Parkinson | TE | Shoulder - AC Joint | Did Not Practice on Friday. Questionable for Week 4 at Philadelphia |
| LAR | Ronnie Rivers | RB | Calf | IR. Injured Reserve. Expected Return - Week 7 |
| LAR | Anthony Torres | TE | Ankle | Questionable for Week 4 at Philadelphia |
| LAR | Myles Garrett | LB | Knee | IR. Injured Reserve. Expected Return - Week 6 |
| LAR | Keagen Trost | OT | Hamstring | IR. Injured Reserve. Expected Return - Week 5 |
| LAR | Jaylen Watson | CB | Shoulder | Out for Week 4 at Philadelphia. Expected Return - Week 5 |
| LAR | Daniel Rickert | LB | Knee | IR. Injured Reserve |
| LAR | Keir Thomas | LB | Groin | IR. Injured Reserve |
| LAR | Alex Johnson | DB | Undisclosed | Questionable for Week 4 at Philadelphia |
| LAR | Drey Norwood | CB | Undisclosed | Questionable for Week 4 at Philadelphia |
| LAR | Matthew Caldwell | QB | Undisclosed | IR. Injured Reserve |
| LAR | Mario Williams | WR | Undisclosed | Questionable for Week 4 at Philadelphia |
| LAR | Terrance Ferguson | TE | Ankle | IR. Injured Reserve. Expected Return - Week 8 |
| LAR | E. Walls III | LB | Undisclosed | IR. Injured Reserve |
| LAR | Darious Williams | DB | Undisclosed | Retired |
| LAR | Justin Dedich | OT | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| LV | Chase Roberts | WR | Undisclosed | Questionable for Week 4 vs. Kansas City |
| LV | D. Thornton Jr. | WR | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| LV | Justin Pickett | G | Undisclosed | IR. Injured Reserve |
| LV | Christian Wilkins | DT | Foot | Questionable for Week 4 vs. Kansas City |
| LV | Jack Bech | WR | Forearm | IR. Injured Reserve. Expected Return - Week 8 |
| LV | Raheem Mostert | RB | Knee | Questionable for Week 4 vs. Kansas City |
| LV | Chris Collier | RB | Undisclosed | IR. Injured Reserve |
| LV | Joshua Miles | OT | Undisclosed | Retired |
| LV | Corey Rucker | WR | Undisclosed | IR. Injured Reserve |
| LV | Chigozie Anusiem | DB | Knee | IR. Injured Reserve |
| LV | Keyron Crawford | DE | Ankle | IR. Injured Reserve |
| LV | Carter Runyon | TE | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| LV | Brennan Jackson | LB | Undisclosed | IR. Injured Reserve |
| MIA | Cole Turner | TE | Undisclosed | IR. Injured Reserve |
| MIA | Zane Gonzalez | K | Undisclosed | Questionable for Week 4 at Minnesota |
| MIA | Carter Warren | OT | Undisclosed | Questionable for Week 4 at Minnesota |
| MIA | Jamaree Salyer | G | Knee | Questionable for Week 4 at Minnesota |
| MIA | Caleb Douglas | WR | Ankle | Out for Week 4 at Minnesota. Expected Return - Week 5 |
| MIA | Omar Brown | DB | Undisclosed | Questionable for Week 4 at Minnesota |
| MIA | Ben Sims | TE | Undisclosed | Questionable for Week 4 at Minnesota |
| MIA | D. Baker Jr. | CB | Undisclosed | Physically Unable to Perform. Expected Return - Week 5 |
| MIA | De'Von Achane | RB | Knee - ACL | IR. Injured Reserve |
| MIA | Kenneth Grant | DT | Leg | IR. Injured Reserve. Expected Return - Week 5 |
| MIA | Storm Duck | CB | Knee | Physically Unable to Perform. Expected Return - Week 5 |
| MIA | Kyle Louis | LB | Knee | IR. Injured Reserve. Expected Return - Week 7 |
| MIA | Ethan Robinson | CB | Undisclosed | Questionable for Week 4 at Minnesota |
| MIA | Rene Konga | DE | Undisclosed | IR. Injured Reserve |
| MIA | Tyreek Hill | WR | Knee - ACL | Out for Week 4 at Minnesota. Expected Return - Week 7 |
| MIA | R. Harrison Jr. | LB | Hamstring | IR. Injured Reserve. Expected Return - Week 7 |
| MIA | Trey Moore | LB | Ankle | IR. Injured Reserve. Expected Return - Week 5 |
| MIA | Lonnie Johnson | SAF | Leg | Questionable for Week 4 at Minnesota |
| MIA | R. Beal Jr. | DE | Hamstring | Out for Week 4 at Minnesota. Expected Return - Week 5 |
| MIN | Luke Wysong | WR | Undisclosed | Questionable for Week 4 vs. Miami |
| MIN | Josh Oliver | TE | Biceps | IR. Injured Reserve |
| MIN | Justin Jefferson | WR | Ankle | Out for Week 4 vs. Miami. Expected Return - Week 5 |
| MIN | Tyreek Chappell | CB | Undisclosed | IR. Injured Reserve |
| MIN | Jaylon Hutchings | DE | Undisclosed | Questionable for Week 4 vs. Miami |
| MIN | Michael Jurgens | G | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| MIN | Jordan Mason | RB | Thumb | IR. Injured Reserve. Expected Return - Week 7 |
| MIN | Bryson Nesbit | TE | Undisclosed | Questionable for Week 4 vs. Miami |
| MIN | Ben Yurosek | TE | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| MIN | Jeff Okudah | CB | Concussion | Questionable for Week 4 vs. Miami |
| MIN | Kejon Owens | RB | Illness | Questionable for Week 4 vs. Miami |
| MIN | Matt Nelson | OT | Undisclosed | Questionable for Week 4 vs. Miami |
| MIN | Tyler Batty | LB | Knee - ACL | IR. Injured Reserve |
| MIN | Brett Thorson | P | Hamstring | Out for Week 4 vs. Miami. Expected Return - Week 5 |
| MIN | Marcus Allen | DB | Undisclosed | Questionable for Week 4 vs. Miami |
| MIN | Jamal Adams | LB | Quadriceps | IR. Injured Reserve |
| MIN | Nick Samac | C | Knee | IR. Injured Reserve. Expected Return - Week 8 |
| MIN | Charles Demmings | CB | Hamstring | Out for Week 4 vs. Miami. Expected Return - Week 5 |
| MIN | Jermar Jefferson | RB | Undisclosed | Questionable for Week 4 vs. Miami |
| MIN | Taki Taimani | DL | Undisclosed | Questionable for Week 4 vs. Miami |
| MIN | C.J. Ham | FB | Undisclosed | Retired |
| NE | Christian Gonzalez | CB | Shoulder | Out for Week 4 at Buffalo. Expected Return - Week 5 |
| NE | A.J. Brown | WR | Ankle | IR. Injured Reserve. Expected Return - Week 8 |
| NE | Reggie Gilliam | RB | Knee | Limited Practice on Friday. Questionable for Week 4 at Buffalo |
| NE | Craig Woodson | SAF | Shoulder | Limited Practice on Friday. Questionable for Week 4 at Buffalo |
| NE | Bryce Baringer | P | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| NE | Myles Montgomery | RB | Undisclosed | IR. Injured Reserve |
| NE | Isaiah Iton | DE | Undisclosed | Questionable for Week 4 at Buffalo |
| NE | Eli Raridon | TE | Thigh | Limited Practice on Friday. Questionable for Week 4 at Buffalo |
| NE | Marcus Bryant | OT | Ankle | IR. Injured Reserve. Expected Return - Week 5 |
| NE | Khalil Jacobs | LB | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| NE | Quintayvious Hutchins | LB | Knee | IR. Injured Reserve. Expected Return - Week 7 |
| NE | Greg Van Roten | G | Thigh | IR. Injured Reserve. Expected Return - Week 8 |
| NE | Brenden Schooler | SAF | Back | NFI-R for Week 4 at Buffalo |
| NE | Dre'Mont Jones | LB | Shoulder | Limited Practice on Friday. Questionable for Week 4 at Buffalo |
| NE | Eric Butler | SAF | Undisclosed | Questionable for Week 4 at Buffalo |
| NE | Morgan Moses | OT | Foot | Limited Practice on Friday. Questionable for Week 4 at Buffalo |
| NE | Shane Zylstra | TE | Undisclosed | Questionable for Week 4 at Buffalo |
| NE | Julian Hill | TE | Knee | IR. Injured Reserve |
| NE | Mike Onwenu | G | Ankle | IR. Injured Reserve. Expected Return - Week 7 |
| NE | Andrew Rupcich | G | Undisclosed | Questionable for Week 4 at Buffalo |
| NE | H. Landry III | LB | Undisclosed | Physically Unable to Perform. Expected Return - Week 5 |
| NE | Jeremiah Webb | WR | Arm | IR. Injured Reserve |
| NE | Jimmy Kibble | WR | Undisclosed | Questionable for Week 4 at Buffalo |
| NE | Christian Elliss | LB | Chest | Limited Practice on Friday. Questionable for Week 4 at Buffalo |
| NE | Dell Pettus | SAF | Ankle | IR. Injured Reserve. Expected Return - Week 7 |
| NO | L. Styles Jr. | SAF | Calf | IR. Injured Reserve. Expected Return - Week 5 |
| NO | Ja'Lynn Polk | WR | Undisclosed | Retired |
| NO | Bryan Bresee | DT | Knee - ACL | IR. Injured Reserve |
| NO | Zach Wood | LS | Calf | IR. Injured Reserve. Expected Return - Week 6 |
| NO | Keeshawn Silver | DT | Undisclosed | Questionable for Week 4 vs. Atlanta |
| NO | Damien Alford | WR | Undisclosed | Questionable for Week 4 vs. Atlanta |
| NO | Travis Etienne | RB | Hamstring | IR. Injured Reserve. Expected Return - Week 9 |
| NO | Barry Wesley | OT | Undisclosed | Questionable for Week 4 vs. Atlanta |
| NO | Nick Saldiveri | G | Knee | Physically Unable to Perform |
| NO | Mason Tipton | WR | Leg | Physically Unable to Perform. Expected Return - Week 5 |
| NO | Rejzohn Wright | DB | Hip | IR. Injured Reserve |
| NO | Dillon Radunz | OT | Knee - ACL | IR. Injured Reserve |
| NO | David Long | DB | Undisclosed | IR. Injured Reserve |
| NO | Noah Fant | TE | Abdomen | Limited Practice on Saturday. Questionable for Week 4 vs. Atlanta |
| NO | Ty Chandler | RB | Knee | IR. Injured Reserve |
| NO | Dalys Beanum | CB | Undisclosed | Questionable for Week 4 vs. Atlanta |
| NO | K. Banks Jr. | OT | Ankle | IR. Injured Reserve. Expected Return - Week 12 |
| NO | Derek Carr | QB | Undisclosed | Retired |
| NO | Jaylan Ford | LB | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| NO | Moliki Matavao | TE | Knee | IR. Injured Reserve |
| NYG | Jarrick Bernard-Converse | CB | Knee | IR. Injured Reserve |
| NYG | Dante Miller | RB | Groin | Questionable for Week 4 vs. Arizona |
| NYG | C. Austin III | WR | Knee | IR. Injured Reserve |
| NYG | Gunner Olszewski | WR | Achilles | IR. Injured Reserve |
| NYG | Rico Payton | CB | Undisclosed | IR. Injured Reserve |
| NYG | Korie Black | CB | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| NYG | Paulson Adebo | CB | Knee | IR. Injured Reserve. Expected Return - Week 6 |
| NYG | Thaddeus Dixon | CB | Achilles | IR. Injured Reserve |
| NYG | Ben Sauls | K | Undisclosed | Questionable for Week 4 vs. Arizona |
| NYG | D.J. James | CB | Undisclosed | Questionable for Week 4 vs. Arizona |
| NYG | Roy Robertson-Harris | DE | Achilles | IR. Injured Reserve |
| NYG | Jaxson Dart | QB | Knee - Meniscus | IR. Injured Reserve |
| NYG | Sam Roberts | DT | Undisclosed | Questionable for Week 4 vs. Arizona |
| NYG | Brian Burns | LB | Knee - ACL | IR. Injured Reserve |
| NYJ | Caullin Lacy | WR | Undisclosed | Questionable for Week 4 at Chicago |
| NYJ | Mason Taylor | TE | Thumb | Out for Week 4 at Chicago. Expected Return - Week 5 |
| NYJ | Tim Patrick | WR | Groin | IR. Injured Reserve. Expected Return - Week 5 |
| NYJ | Breece Hall | RB | Quadriceps | Out for Week 4 at Chicago. Expected Return - Week 5 |
| NYJ | Chip Trayanum | RB | Neck | IR. Injured Reserve |
| NYJ | Dominic Richardson | RB | Undisclosed | Questionable for Week 4 at Chicago |
| NYJ | Tyler Baron | DE | Knee | Physically Unable to Perform. Expected Return - Week 5 |
| NYJ | Connor Hulstein | TE | Undisclosed | Questionable for Week 4 at Chicago |
| NYJ | O. Cooper Jr. | WR | Ankle | IR. Injured Reserve. Expected Return - Week 6 |
| NYJ | Adonai Mitchell | WR | Finger | Out for Week 4 at Chicago. Expected Return - Week 5 |
| NYJ | Francisco Mauigoa | LB | Quadriceps | Out for Week 4 at Chicago. Expected Return - Week 5 |
| NYJ | VJ Payne | SAF | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| NYJ | Marcelino McCrary-Ball | LB | Ankle | IR. Injured Reserve. Expected Return - Week 7 |
| NYJ | Christopher Smith | S | Undisclosed | Questionable for Week 4 at Chicago |
| NYJ | DT Sheffield | WR | Undisclosed | Questionable for Week 4 at Chicago |
| NYJ | Keilan Robinson | RB | Undisclosed | Questionable for Week 4 at Chicago |
| NYJ | Anez Cooper | G | Shoulder | IR. Injured Reserve. Expected Return - Week 5 |
| NYJ | David Onyemata | DT | Groin | IR. Injured Reserve. Expected Return - Week 9 |
| NYJ | Kingsley Enagbare | LB | Knee | Limited Practice on Friday. Questionable for Week 4 at Chicago |
| NYJ | G. Scott Jr. | WR | Undisclosed | Questionable for Week 4 at Chicago |
| NYJ | Dylan Parham | G | Knee | Out for Week 4 at Chicago. Expected Return - Week 5 |
| NYJ | Chase Curtis | TE | Knee | Questionable for Week 4 at Chicago |
| NYJ | Tre Brown | CB | Finger | IR. Injured Reserve |
| NYJ | Kingsley Jonathan | DE | Thigh | IR. Injured Reserve |
| NYJ | Arian Smith | WR | Knee - ACL | IR. Injured Reserve |
| PHI | Landon Dickerson | G | Knee | IR. Injured Reserve. Expected Return - Week 6 |
| PHI | Tariq Castro-Fields | CB | Heel | Questionable for Week 4 vs. L.A. Rams |
| PHI | Tucker Large | S | Undisclosed | NFI-R for Week 4 vs. L.A. Rams |
| PHI | Chance Campbell | LB | Undisclosed | Out for Week 4 vs. L.A. Rams. Expected Return - Week 8 |
| PHI | Jakorian Bennett | DB | Knee | IR. Injured Reserve. Expected Return - Week 5 |
| PHI | Danny Gray | WR | Undisclosed | Questionable for Week 4 vs. L.A. Rams |
| PHI | Johnny Wilson | WR | Knee | IR. Injured Reserve |
| PHI | DeVonta Smith | WR | Hamstring | Out for Week 4 vs. L.A. Rams. Expected Return - Week 5 |
| PHI | Marcus Epps | SAF | Groin | Out for Week 4 vs. L.A. Rams. Expected Return - Week 5 |
| PHI | Andre' Sam | SAF | Foot | IR. Injured Reserve |
| PHI | Ja'Quinden Jackson | RB | Undisclosed | Questionable for Week 4 vs. L.A. Rams |
| PHI | Fred Johnson | OT | Knee | Out for Week 4 vs. L.A. Rams. Expected Return - Week 5 |
| PHI | Eli Stowers | TE | Hamstring | IR. Injured Reserve. Expected Return - Week 5 |
| PHI | Elijah Mitchell | RB | Undisclosed | Questionable for Week 4 vs. L.A. Rams |
| PHI | Dallas Goedert | TE | Knee - MCL | Out for Week 4 vs. L.A. Rams. Expected Return - Week 5 |
| PHI | Grant Calcaterra | TE | Back | IR. Injured Reserve. Expected Return - Week 5 |
| PIT | Max Hurleman | RB | Undisclosed | Out for Week 5 vs. Indianapolis. Expected Return - Week 6 |
| PIT | Robert Woods | WR | Undisclosed | Retired |
| PIT | Gennings Dunker | G | Knee | IR. Injured Reserve. Expected Return - Week 7 |
| PIT | Donte Kent | CB | Undisclosed | Physically Unable to Perform. Expected Return - Week 5 |
| PIT | Cory Trice | CB | Knee | Questionable for Week 5 vs. Indianapolis |
| PIT | Logan Lee | DT | Undisclosed | IR. Injured Reserve |
| PIT | Israel Mukuamu | SAF | Undisclosed | Questionable for Week 5 vs. Indianapolis |
| PIT | Jacob Slade | DL | Undisclosed | Questionable for Week 5 vs. Indianapolis |
| PIT | Daequan Hardy | CB | Undisclosed | IR. Injured Reserve |
| PIT | Lorenzo Thompson | OT | Undisclosed | Questionable for Week 5 vs. Indianapolis |
| PIT | Adam Thielen | WR | Undisclosed | Retired |
| PIT | Montana Lemonious-Craig | WR | Lower Body | Questionable for Week 5 vs. Indianapolis |
| PIT | DeShon Elliott | SAF | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| PIT | Jack Driscoll | OT | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| PIT | Cole Burgess | WR | Undisclosed | IR. Injured Reserve |
| SEA | Ty Okada | SAF | Hamstring | Full Practice on Friday. Questionable for Week 4 vs. L.A. Chargers |
| SEA | Zach Charbonnet | RB | Knee - ACL | Physically Unable to Perform. Expected Return - Week 5 |
| SEA | Bud Clark | SAF | Ankle | IR. Injured Reserve |
| SEA | Mason Richman | G | Leg | IR. Injured Reserve |
| SEA | Anthony Bradford | G | Knee | IR. Injured Reserve. Expected Return - Week 7 |
| SEA | Tyrone Broden | CB | Undisclosed | Questionable for Week 4 vs. L.A. Chargers |
| SEA | Joseph Vaughn | LB | Undisclosed | Questionable for Week 4 vs. L.A. Chargers |
| SEA | Ja'Markis Weston | LB | Undisclosed | Questionable for Week 4 vs. L.A. Chargers |
| SEA | Chazz Surratt | LB | Calf | Limited Practice on Friday. Questionable for Week 4 vs. L.A. Chargers |
| SEA | Irvin Charles | WR | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| SEA | Robbie Ouzts | RB | Neck | IR. Injured Reserve |
| SEA | Shane Lemieux | OG | Undisclosed | Questionable for Week 4 vs. L.A. Chargers |
| SEA | Terrion Arnold | CB | Personal | Commissioner's exempt list for Week 4 vs. L.A. Chargers. Expected Return - Week 5 |
| SEA | Power Echols | LB | Undisclosed | Questionable for Week 4 vs. L.A. Chargers |
| SEA | Aaron Smith | LB | Undisclosed | Questionable for Week 4 vs. L.A. Chargers |
| SEA | Shemar Jean-Charles | CB | Undisclosed | Questionable for Week 4 vs. L.A. Chargers |
| SEA | Johnathan Hankins | DT | Back | Questionable for Week 4 vs. L.A. Chargers |
| SEA | Jake Bobo | WR | Knee | IR. Injured Reserve |
| SEA | Harrison Bryant | TE | Undisclosed | Questionable for Week 4 vs. L.A. Chargers |
| SF | Nick Zakelj | OT | Undisclosed | IR. Injured Reserve |
| SF | Sam Okuayinonu | DT | Foot | IR. Injured Reserve. Expected Return - Week 15 |
| SF | Austen Pleasants | OL | Knee | IR. Injured Reserve. Expected Return - Week 5 |
| SF | Nate Hobbs | CB | Groin | IR. Injured Reserve. Expected Return - Week 5 |
| SF | Patrick Taylor | RB | Undisclosed | Questionable for Week 4 vs. Denver |
| SF | Nick Bosa | DE | Calf | Out for Week 4 vs. Denver. Expected Return - Week 5 |
| SF | Nick Martin | LB | Hamstring | IR. Injured Reserve. Expected Return - Week 5 |
| SF | Mykel Williams | DE | Knee - ACL | Physically Unable to Perform. Expected Return - Week 5 |
| SF | Jake Tonges | TE | Knee - MCL | IR. Injured Reserve |
| SF | Isaac Guerendo | RB | Pectoral | Physically Unable to Perform. Expected Return - Week 5 |
| SF | Dre Greenlaw | LB | Quadriceps | Limited Practice on Friday. Questionable for Week 4 vs. Denver |
| SF | Alfred Collins | DT | Knee | IR. Injured Reserve |
| SF | Mikail Kamara | DE | Knee | IR. Injured Reserve |
| SF | De'Zhaun Stribling | WR | Ankle | IR. Injured Reserve. Expected Return - Week 11 |
| SF | Darrick Forrest | SAF | Undisclosed | IR. Injured Reserve |
| SF | Demarcus Robinson | WR | Ankle | IR. Injured Reserve. Expected Return - Week 7 |
| SF | Titus Leo | DE | Undisclosed | Questionable for Week 4 vs. Denver |
| SF | CJ West | DT | Undisclosed | IR. Injured Reserve. Expected Return - Week 7 |
| SF | K.J. Henry | DE | Undisclosed | Questionable for Week 4 vs. Denver |
| SF | Brandon Aiyuk | WR | Personal | Did Not Report |
| SF | Tanner McLachlan | TE | Undisclosed | Questionable for Week 4 vs. Denver |
| SF | Jaden Dugger | LB | Shoulder | Limited Practice on Friday. Questionable for Week 4 vs. Denver |
| SF | Brett Toth | G | Concussion | IR. Injured Reserve |
| SF | Isaiah Prince | OT | Knee | Questionable for Week 4 vs. Denver |
| SF | Christian Kirk | WR | Calf | IR. Injured Reserve. Expected Return - Week 5 |
| SF | Andrew Farmer | DE | Back | IR. Injured Reserve |
| SF | J. Thompson Jr. | DT | Ankle | Out for Week 4 vs. Denver. Expected Return - Week 5 |
| SF | Mike Evans | WR | Ribs | Limited Practice on Friday. Questionable for Week 4 vs. Denver |
| SF | Keion White | DE | Hamstring | Limited Practice on Friday. Questionable for Week 4 vs. Denver |
| TB | Rakeem Nunez-Roches | DT | Ankle | Full Practice on Friday. Questionable for Week 4 vs. Green Bay |
| TB | David Sills | WR | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| TB | DJ Williams | RB | Undisclosed | Questionable for Week 4 vs. Green Bay |
| TB | Ja'Qurious Conley | SAF | Undisclosed | Questionable for Week 4 vs. Green Bay |
| TB | Josh Hayes | DB | Knee | IR. Injured Reserve. Expected Return - Week 5 |
| TB | Baker Mayfield | QB | Thumb | Out for Week 4 vs. Green Bay. Expected Return - Week 7 |
| TB | Chase Lucas | CB | Undisclosed | Questionable for Week 4 vs. Green Bay |
| TB | SirVocea Dennis | LB | Calf | Limited Practice on Friday. Questionable for Week 4 vs. Green Bay |
| TB | Jalen McMillan | WR | Knee - PCL | IR. Injured Reserve. Expected Return - Week 11 |
| TB | Marcus Banks | DB | Undisclosed | Questionable for Week 4 vs. Green Bay |
| TB | Kadarius Calloway | RB | Undisclosed | Questionable for Week 4 vs. Green Bay |
| TB | Kemon Hall | DB | Undisclosed | Questionable for Week 4 vs. Green Bay |
| TB | Mohamed Kamara | LB | Knee | IR. Injured Reserve |
| TB | Benjamin Morrison | CB | Quadriceps | Out for Week 4 vs. Green Bay. Expected Return - Week 6 |
| TB | Dennis Houston | WR | Groin | Questionable for Week 4 vs. Green Bay |
| TB | Ko Kieft | TE | Elbow | Out for Week 4 vs. Green Bay. Expected Return - Week 6 |
| TB | Damarion Williams | CB | Undisclosed | Questionable for Week 4 vs. Green Bay |
| TB | Xavier Williams | SAF | Hip | Questionable for Week 4 vs. Green Bay |
| TB | Deshawn McKnight | DT | Hamstring | Questionable for Week 4 vs. Green Bay |
| TEN | Kendell Brooks | SAF | Undisclosed | IR. Injured Reserve |
| TEN | Jalyn Armour-Davis | CB | Achilles | Questionable for Week 4 at Baltimore |
| TEN | Joshua Williams | CB | Pectoral | IR. Injured Reserve. Expected Return - Week 5 |
| TEN | Fernando Carmona | G | Ankle | IR. Injured Reserve. Expected Return - Week 8 |
| TEN | Jaylen Harrell | DE | Knee - ACL | IR. Injured Reserve |
| TEN | Dorian Mausi | LB | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| TEN | Sean Brown | LB | Undisclosed | Questionable for Week 4 at Baltimore |
| TEN | S. Banks Jr. | LB | Undisclosed | Questionable for Week 4 at Baltimore |
| TEN | Milo Eifler | LB | Undisclosed | IR. Injured Reserve |
| TEN | Dominique Hampton | LB | Undisclosed | Questionable for Week 4 at Baltimore |
| TEN | Tanoh Kpassagnon | DE | Undisclosed | IR. Injured Reserve |
| TEN | Justin Hardee | DB | Undisclosed | Questionable for Week 4 at Baltimore |
| TEN | Jackson Slater | G | Foot | IR. Injured Reserve. Expected Return - Week 8 |
| TEN | K. Winston Jr. | SAF | Shoulder | Did Not Practice on Friday. Questionable for Week 4 at Baltimore |
| TEN | Tyjae Spears | RB | Ankle | Full Practice on Friday. Questionable for Week 4 at Baltimore |
| TEN | Nazeeh Johnson | CB | Ankle | Questionable for Week 4 at Baltimore |
| TEN | Jaren Kanak | TE | Pectoral | IR. Injured Reserve |
| WAS | M. Jones Jr. | LB | Undisclosed | Questionable for Week 5 vs. N.Y. Giants |
| WAS | Trey Amos | CB | Ankle | IR. Injured Reserve. Expected Return - Week 5 |
| WAS | Jeremy McNichols | RB | Quadriceps | IR. Injured Reserve. Expected Return - Week 5 |
| WAS | Curtis Jacobs | LB | Undisclosed | Questionable for Week 5 vs. N.Y. Giants |
| WAS | D. Wise Jr. | DE | Quadriceps | Physically Unable to Perform. Expected Return - Week 5 |
| WAS | Nick Bellore | LB | Personal | Retired |
| WAS | Leo Chenal | LB | Neck | IR. Injured Reserve |
| WAS | Laremy Tunsil | OT | Triceps | IR. Injured Reserve. Expected Return - Week 15 |
| WAS | Johnny Newton | DT | Pectoral | IR. Injured Reserve. Expected Return - Week 11 |
| WAS | Jacoby Jones | WR | Undisclosed | Questionable for Week 5 vs. N.Y. Giants |
| WAS | Tyler Cooper | G | Undisclosed | Questionable for Week 5 vs. N.Y. Giants |
| WAS | Quentin Moore | TE | Undisclosed | Questionable for Week 5 vs. N.Y. Giants |
| WAS | River Cracraft | WR | Undisclosed | Questionable for Week 5 vs. N.Y. Giants |
| WAS | Jordan Magee | LB | Hamstring | IR. Injured Reserve. Expected Return - Week 6 |
| WAS | D.J. Davidson | DT | Undisclosed | Retired |
| WAS | Ahkello Witherspoon | CB | Personal | Retired |
| CLE | Tylan Wallace | WR | Knee | Inactive for Week 4 vs Pittsburgh |
| CLE | Justin Jefferson | LB | Coach's Decision | Inactive for Week 4 vs Pittsburgh |
| CLE | Taylen Green | QB | Coach's Decision | Inactive for Week 4 vs. Pittsburgh |
| CLE | Elgton Jenkins | C | Concussion | Inactive for Week 4 vs Pittsburgh |
| PIT | Rico Dowdle | RB | Toe | Inactive for Week 4 at Cleveland |
| PIT | Will Howard | QB | Coach's Decision | Inactive for Week 4 at Cleveland |
| PIT | K. Jobity Jr. | DT | Coach's Decision | Inactive for Week 4 at Cleveland |
| PIT | Drew Allar | QB | Coach's Decision | Inactive for Week 4 at Cleveland |
| PIT | Gabriel Rubio | DE | Coach's Decision | Inactive for Week 4 at Cleveland |
| PIT | Eli Heidenreich | RB | Coach's Decision | Inactive for Week 4 at Cleveland |
| DAL | DJ Rogers | TE | Knee | IR. Injured Reserve |
| LAC | Tyler Biadasz | C | Knee | IR. Injured Reserve |
| SF | Ricky Pearsall | WR | Knee - PCL | IR. Injured Reserve |
| ARI | Joey Blount | SAF | Neck | IR. Injured Reserve |
| Player | Pos | Injury | Status | |
|---|---|---|---|---|
| ARI | Joey Blount | SAF | Neck | IR. Injured Reserve |
| ARI | Dadrion Taylor-Demerson | SAF | Back | Inactive for Week 4 at N.Y. Giants |
| ARI | Josh Fryar | OT | Coach's Decision | — |
| ARI | Reggie Virgil | WR | Coach's Decision | Inactive for Week 4 at N.Y. Giants |
| ARI | Carson Beck | QB | Coach's Decision | Inactive for Week 4 at N.Y. Giants |
| ARI | S. Thomas V | CB | Coach's Decision | — |
| ARI | Will Johnson | CB | Neck | IR. Injured Reserve |
| ARI | Chase Bisontis | OT | Knee - MCL | IR. Injured Reserve |
| ARI | Josh Minkins | DB | Undisclosed | Questionable for Week 4 at N.Y. Giants |
| ARI | Andre Baccellia | WR | Neck | Questionable for Week 4 at N.Y. Giants |
| ARI | Tip Reiman | TE | Ankle | Physically Unable to Perform. Expected Return - Week 5 |
| ARI | Kitan Crawford | SAF | Ankle | IR. Injured Reserve. Expected Return - Week 6 |
| ARI | Jameson Geers | TE | Undisclosed | IR. Injured Reserve |
| ARI | JJ Russell | ILB | Concussion | Questionable for Week 4 at N.Y. Giants |
| ARI | Trey Benson | RB | Knee | IR. Injured Reserve |
| ARI | Zachary Carter | DT | Knee | IR. Injured Reserve. Expected Return - Week 5 |
| ARI | Kenny Yeboah | TE | Hamstring | Questionable for Week 4 at N.Y. Giants |
| ARI | Jonah Williams | OT | Shoulder | Questionable for Week 4 at N.Y. Giants |
| ARI | James Conner | RB | Foot | IR. Injured Reserve. Expected Return - Week 5 |
| ARI | Xavier Weaver | WR | Hamstring | Questionable for Week 4 at N.Y. Giants |
| ARI | Kaleb Proctor | DT | Knee - Meniscus | IR. Injured Reserve |
| ARI | Bilal Nichols | DT | Knee | Questionable for Week 4 at N.Y. Giants |
| ARI | Justin Jones | DT | Knee | Questionable for Week 4 at N.Y. Giants |
| ATL | Kaleb McGary | OT | Leg | Retired |
| ATL | Divine Deablo | LB | Hamstring | Limited Practice on Saturday. Questionable for Week 4 at New Orleans |
| ATL | A.J. Terrell | CB | Groin | IR. Injured Reserve. Expected Return - Week 7 |
| ATL | Troy Andersen | LB | Knee | Questionable for Week 4 at New Orleans |
| ATL | Da'Shawn Hand | DE | Quadriceps | IR. Injured Reserve |
| ATL | Malik Verdon | LB | Undisclosed | Questionable for Week 4 at New Orleans |
| ATL | T. Wheatley Jr. | OT | Undisclosed | Questionable for Week 4 at New Orleans |
| ATL | DeAngelo Malone | LB | Undisclosed | Physically Unable to Perform |
| ATL | Beaux Collins | WR | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| ATL | Trey Sermon | RB | Undisclosed | IR. Injured Reserve |
| ATL | Jalon Walker | LB | Knee - ACL | IR. Injured Reserve |
| ATL | Anterio Thompson | DT | Undisclosed | NFI-R for Week 4 at New Orleans |
| ATL | JD Bertrand | LB | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| ATL | Le'Meke Brockington | WR | Undisclosed | Questionable for Week 4 at New Orleans |
| ATL | Cameron Williams | OT | Ankle | IR. Injured Reserve. Expected Return - Week 5 |
| ATL | Samson Ebukam | DE | Hamstring | Full Practice on Saturday. Questionable for Week 4 at New Orleans |
| ATL | Storm Norton | OT | Foot | Physically Unable to Perform |
| ATL | Kevin King | CB | Undisclosed | Questionable for Week 4 at New Orleans |
| ATL | Jamal Agnew | WR | Undisclosed | Questionable for Week 4 at New Orleans |
| BAL | Jovaughn Gwyn | C | Ankle | IR. Injured Reserve. Expected Return - Week 14 |
| BAL | Ethan Pocic | C | Knee | IR. Injured Reserve. Expected Return - Week 8 |
| BAL | Trey Hendrickson | LB | Finger | Out for Week 4 vs. Tennessee. Expected Return - Week 5 |
| BAL | Adam Randall | RB | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| BAL | Reid Williford | LB | Undisclosed | Questionable for Week 4 vs. Tennessee |
| BAL | Bilhal Kone | CB | Lower Body | IR. Injured Reserve. Expected Return - Week 5 |
| BAL | Ja'Kobi Lane | WR | Wrist | IR. Injured Reserve. Expected Return - Week 6 |
| BAL | Deonte Harty | WR | Knee | Questionable for Week 4 vs. Tennessee |
| BAL | T.J. Tampa | CB | Knee | IR. Injured Reserve. Expected Return - Week 6 |
| BAL | Danny Pinter | G | Knee | IR. Injured Reserve |
| BAL | Kendall Lamm | OT | Undisclosed | Retired |
| BAL | Jahquez Robinson | SAF | Undisclosed | IR. Injured Reserve |
| BAL | Chris Moore | WR | Ankle | Limited Practice on Friday. Questionable for Week 4 vs. Tennessee |
| BAL | Skylar Thompson | QB | Undisclosed | IR. Injured Reserve |
| BAL | Ronnie Stanley | OT | Toe | Did Not Practice on Friday. Questionable for Week 4 vs. Tennessee |
| BUF | Skyler Bell | WR | Coach's Decision | Inactive for Week 4 vs. New England |
| BUF | Christian Benford | CB | Toe | Inactive for Week 4 vs. New England |
| BUF | Jude Bowry | OT | Coach's Decision | Inactive for Week 4 vs. New England |
| BUF | Dorian Strong | CB | Neck | NFI-R for Week 4 vs. New England |
| BUF | Tyrell Shavers | WR | Knee - ACL | Physically Unable to Perform. Expected Return - Week 5 |
| BUF | Jordan Poyer | FS | Hamstring | Questionable for Week 4 vs. New England |
| BUF | Jordan Hancock | CB | Hamstring | IR. Injured Reserve. Expected Return - Week 8 |
| BUF | Jalen Virgil | WR | Undisclosed | Questionable for Week 4 vs. New England |
| BUF | Zane Durant | DT | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| BUF | T.J. Sanders | DT | Appendix | Limited Practice on Friday. Doubtful for Week 4 vs. New England |
| BUF | Demetrius Flannigan-Fowles | LB | Undisclosed | Questionable for Week 4 vs. New England |
| BUF | Ray Davis | RB | Hamstring | Limited Practice on Friday. Questionable for Week 4 vs. New England |
| BUF | Jordan Phillips | DT | Ankle | Questionable for Week 4 vs. New England |
| BUF | BoseGrant DuBose | WR | Shoulder | Questionable for Week 4 vs. New England |
| CAR | Cam Jackson | DT | Knee | Limited Practice on Friday. Questionable for Week 4 vs. Detroit |
| CAR | Xavier Legette | WR | Knee | IR. Injured Reserve. Expected Return - Week 9 |
| CAR | Damien Lewis | G | Elbow | Out for Week 4 vs. Detroit. Expected Return - Week 6 |
| CAR | Trevor Etienne | RB | Ankle | IR. Injured Reserve. Expected Return - Week 6 |
| CAR | C. Brazzell II | WR | Knee | IR. Injured Reserve |
| CAR | Brady Christensen | OT | Hamstring | IR. Injured Reserve. Expected Return - Week 6 |
| CAR | Mike Jackson | CB | Groin | IR. Injured Reserve. Expected Return - Week 11 |
| CAR | Taylor Moton | OT | Illness | NFI-R for Week 4 vs. Detroit |
| CAR | Amare Barno | LB | Knee | Questionable for Week 4 vs. Detroit |
| CAR | Jalen Coker | WR | Quadriceps | Limited Practice on Friday. Questionable for Week 4 vs. Detroit |
| CAR | Ainias Smith | WR | Undisclosed | Questionable for Week 4 vs. Detroit |
| CAR | LaBryan Ray | DT | Personal | Retired |
| CAR | Josey Jewell | ILB | Concussion | Questionable for Week 4 vs. Detroit |
| CAR | Ryan Hayes | OT | Undisclosed | Questionable for Week 4 vs. Detroit |
| CAR | Will Grier | QB | Personal | Retired |
| CAR | Lee Hunter | DT | Foot | Limited Practice on Friday. Questionable for Week 4 vs. Detroit |
| CAR | Jaycee Horn | CB | Quadriceps | IR. Injured Reserve. Expected Return - Week 10 |
| CAR | Jonathon Brooks | RB | Abdomen | IR. Injured Reserve. Expected Return - Week 9 |
| CAR | Ikem Ekwonu | OT | Knee | Physically Unable to Perform. Expected Return - Week 6 |
| CAR | Bam Martin-Scott | LB | Hamstring | IR. Injured Reserve. Expected Return - Week 6 |
| CAR | Tyler Mabry | TE | Undisclosed | Questionable for Week 4 vs. Detroit |
| CAR | Dan Chisena | WR | Undisclosed | Questionable for Week 4 vs. Detroit |
| CAR | Tershawn Wharton | DE | Neck | Physically Unable to Perform. Expected Return - Week 6 |
| CAR | Claudin Cherelus | LB | Shoulder | Questionable for Week 4 vs. Detroit |
| CAR | Nic Scourton | LB | Knee - ACL | IR. Injured Reserve |
| CHI | Caleb Williams | QB | Hamstring | Inactive for Week 4 vs. N.Y. Jets |
| CHI | Ozzy Trapilo | OT | Coach's Decision | — |
| CHI | James Lynch | DT | Coach's Decision | — |
| CHI | Cam Lewis | CB | Hip | Inactive for Week 4 vs. N.Y. Jets |
| CHI | Jayden Loving | DT | Coach's Decision | — |
| CHI | Jamree Kromah | DE | Coach's Decision | — |
| CHI | Braxton Jones | OT | Knee | IR. Injured Reserve. Expected Return - Week 8 |
| CHI | Kyron Hudson | WR | Undisclosed | Questionable for Week 4 vs. N.Y. Jets |
| CHI | Nikola Kalinic | TE | Knee | IR. Injured Reserve |
| CHI | Dallis Flowers | CB | Leg | IR. Injured Reserve |
| CHI | Kyler Gordon | CB | Calf | Physically Unable to Perform. Expected Return - Week 5 |
| CHI | Drew Dalman | C | Undisclosed | Retired |
| CHI | Jonathan Garvin | DE | Undisclosed | IR. Injured Reserve |
| CHI | Hayden Large | TE | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| CHI | Dontae Manning | CB | Undisclosed | Questionable for Week 4 vs. N.Y. Jets |
| CHI | Nephi Sewell | LB | Concussion | IR. Injured Reserve |
| CHI | Brittain Brown | RB | Undisclosed | IR. Injured Reserve |
| CHI | Ray-Ray McCloud | WR | Undisclosed | Questionable for Week 4 vs. N.Y. Jets |
| CHI | A. Johnson Jr. | SAF | Undisclosed | Out for Week 4 vs. N.Y. Jets. Expected Return - Week 6 |
| CHI | Shemar Turner | DT | Knee - ACL | Physically Unable to Perform. Expected Return - Week 5 |
| CHI | Ty Summers | LB | Foot | Questionable for Week 4 vs. N.Y. Jets |
| CHI | Jaylon Jones | DB | Hamstring | Questionable for Week 4 vs. N.Y. Jets |
| CHI | Ricky Stromberg | OL | Undisclosed | Questionable for Week 4 vs. N.Y. Jets |
| CHI | Gervarrius Owens | SAF | Undisclosed | Questionable for Week 4 vs. N.Y. Jets |
| CHI | Noah Sewell | LB | Achilles | Physically Unable to Perform. Expected Return - Week 5 |
| CHI | R. Hyppolite II | LB | Shoulder | IR. Injured Reserve |
| CHI | T. Fields II | LB | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| CHI | Anthony Johnson | CB | Undisclosed | IR. Injured Reserve. Expected Return - Week 6 |
| CHI | KC Eziomume | DB | Undisclosed | Questionable for Week 4 vs. N.Y. Jets |
| CHI | Coby Bryant | CB | Knee | IR. Injured Reserve. Expected Return - Week 15 |
| CIN | Swayze Bozeman | LB | Groin | Inactive for Week 4 vs. Jacksonville |
| CIN | Bryan Cook | SAF | Ankle | Limited Practice on Friday. Questionable for Week 4 vs. Jacksonville |
| CIN | Zack Moss | RB | Neck | Questionable for Week 4 vs. Jacksonville |
| CIN | B. Parker II | OT | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| CIN | Ja'Sir Taylor | CB | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| CIN | Jalen Davis | CB | Hamstring | IR. Injured Reserve. Expected Return - Week 9 |
| CIN | Dalton Risner | G | Knee | Full Practice on Friday. Questionable for Week 4 vs. Jacksonville |
| CIN | Andrei Iosivas | WR | Thumb | IR. Injured Reserve. Expected Return - Week 8 |
| CIN | B.J. Hill | DT | Achilles | Limited Practice on Friday. Questionable for Week 4 vs. Jacksonville |
| CIN | Jaxson Kirkland | OG | Undisclosed | Questionable for Week 4 vs. Jacksonville |
| CIN | Colbie Young | WR | Knee | Out for Week 4 vs. Jacksonville. Expected Return - Week 5 |
| CIN | Kyle Dugger | SAF | Quadriceps | Out for Week 4 vs. Jacksonville. Expected Return - Week 5 |
| CLE | Jamari Thrash | WR | Undisclosed | Questionable for Week 5 at N.Y. Jets |
| CLE | Tyron Herring | SAF | Undisclosed | Questionable for Week 5 at N.Y. Jets |
| CLE | Damarri Mathis | DB | Undisclosed | IR. Injured Reserve |
| CLE | Jeremiah Owusu-Koramoah | LB | Neck | Physically Unable to Perform |
| CLE | Nathaniel Watson | LB | Knee | Out for Week 5 at N.Y. Jets. Expected Return - Week 7 |
| CLE | Markees Watts | LB | Undisclosed | Retired |
| CLE | Dylan Sampson | RB | Knee | IR. Injured Reserve. Expected Return - Week 6 |
| CLE | Mason Graham | DT | Knee | Questionable for Week 5 at N.Y. Jets |
| CLE | Edefuan Ulofoshio | LB | Biceps | IR. Injured Reserve |
| CLE | Elgton Jenkins | C | Concussion | Inactive for Week 4 vs Pittsburgh |
| CLE | Taylen Green | QB | Coach's Decision | Inactive for Week 4 vs. Pittsburgh |
| CLE | Justin Jefferson | LB | Coach's Decision | Inactive for Week 4 vs Pittsburgh |
| CLE | Tylan Wallace | WR | Knee | Inactive for Week 4 vs Pittsburgh |
| CLE | Travis Bell | DT | Eye | Questionable for Week 5 at N.Y. Jets |
| CLE | Teven Jenkins | G | Back | Inactive for Week 4 vs. Pittsburgh |
| CLE | Alex Wright | DE | Achilles | IR. Injured Reserve |
| CLE | Elijah Chatman | DT | Quadriceps | IR. Injured Reserve |
| CLE | Aaron Anderson | WR | Undisclosed | Questionable for Week 5 at N.Y. Jets |
| CLE | Kalia Davis | DT | Quadriceps | IR. Injured Reserve. Expected Return - Week 5 |
| CLE | Dom Jones | CB | Knee | Questionable for Week 5 at N.Y. Jets |
| CLE | Tyreak Sapp | DE | Undisclosed | Questionable for Week 5 at N.Y. Jets |
| CLE | Dillon Gabriel | QB | Back | IR. Injured Reserve. Expected Return - Week 5 |
| CLE | Joe Royer | TE | Personal | NFI-R for Week 5 at N.Y. Jets |
| DAL | Devin Moore | CB | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| DAL | Matt Hennessy | C | Neck | IR. Injured Reserve |
| DAL | Jalen Thompson | DB | Hamstring | IR. Injured Reserve. Expected Return - Week 8 |
| DAL | Malik Davis | RB | Hip | IR. Injured Reserve |
| DAL | P.J. Locke | DB | Foot | IR. Injured Reserve. Expected Return - Week 7 |
| DAL | Marist Liufau | LB | Forearm | IR. Injured Reserve. Expected Return - Week 5 |
| DAL | Jonathan Bullard | DE | Calf | IR. Injured Reserve. Expected Return - Week 8 |
| DAL | Tyler Smith | G | Thumb | IR. Injured Reserve. Expected Return - Week 5 |
| DAL | DeMarvion Overshown | LB | Hamstring | Out for Week 4 at Houston. Expected Return - Week 6 |
| DAL | Princeton Fant | TE | Knee - ACL + MCL | IR. Injured Reserve |
| DAL | Decobie Durant | CB | Hamstring | Out for Week 4 at Houston. Expected Return - Week 6 |
| DAL | K. Gilliam Jr. | DT | Triceps | IR. Injured Reserve |
| DAL | DJ Rogers | TE | Knee | IR. Injured Reserve |
| DAL | Camden Brown | WR | Coach's Decision | Inactive for Week 4 at Houston |
| DEN | Jonah Coleman | RB | Ankle | IR. Injured Reserve. Expected Return - Week 7 |
| DEN | Dondrea Tillman | LB | Hamstring | Out for Week 4 at San Francisco. Expected Return - Week 5 |
| DEN | Michael Deiter | C | Quadriceps | IR. Injured Reserve |
| DEN | Caleb Lohner | TE | Lower Body | IR. Injured Reserve. Expected Return - Week 5 |
| DEN | Levelle Bailey | LB | Leg | IR. Injured Reserve |
| DEN | Drew Sanders | LB | Undisclosed | Questionable for Week 4 at San Francisco |
| DEN | Blake Cotton | DB | Hamstring | Questionable for Week 4 at San Francisco |
| DEN | Nick Gargiulo | G | Knee - ACL | Physically Unable to Perform. Expected Return - Week 5 |
| DEN | Frank Crum | OT | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| DEN | M. Woods II | WR | Leg | Questionable for Week 4 at San Francisco |
| DEN | Matt Henningsen | DE | Achilles | IR. Injured Reserve |
| DET | Luke Deal | TE | Undisclosed | Questionable for Week 4 at Carolina |
| DET | Thomas Harper | SAF | Ankle | IR. Injured Reserve. Expected Return - Week 8 |
| DET | De'Shawn Rucker | CB | Ankle | Questionable for Week 4 at Carolina |
| DET | Emmanuel Moseley | DB | Illness | Questionable for Week 4 at Carolina |
| DET | Damone Clark | LB | Undisclosed | IR. Injured Reserve |
| DET | Cade Mays | C | Wrist | IR. Injured Reserve. Expected Return - Week 7 |
| DET | Kye Robichaux | RB | Foot | Questionable for Week 4 at Carolina |
| DET | C. Wilson Jr. | WR | Knee | Questionable for Week 4 at Carolina |
| DET | M. Norris Jr. | SAF | Concussion | Questionable for Week 4 at Carolina |
| DET | Dicaprio Bootle | CB | Undisclosed | Questionable for Week 4 at Carolina |
| DET | Divaad Wilson | CB | Undisclosed | Questionable for Week 4 at Carolina |
| DET | Giovanni Manu | OL | Knee | NFI-R for Week 4 at Carolina |
| DET | Raheem Blackshear | RB | Undisclosed | Questionable for Week 4 at Carolina |
| DET | Isiah Pacheco | RB | Back | IR. Injured Reserve. Expected Return - Week 13 |
| DET | Michael Niese | G | Leg | Questionable for Week 4 at Carolina |
| DET | Avonte Maddox | FS | Foot | IR. Injured Reserve |
| DET | Kerby Joseph | SAF | Knee | Physically Unable to Perform. Expected Return - Week 5 |
| DET | Jamarco Jones | OT | Achilles | Questionable for Week 4 at Carolina |
| DET | Brian Branch | CB | Achilles | Physically Unable to Perform. Expected Return - Week 5 |
| DET | Teddy Bridgewater | QB | Undisclosed | Retired |
| DET | Zach Cunningham | ILB | Hamstring | Questionable for Week 4 at Carolina |
| DET | Aidan Keanaaina | DT | Undisclosed | Questionable for Week 4 at Carolina |
| DET | D.J. Reed | CB | Ribs | Limited Practice on Friday. Questionable for Week 4 at Carolina |
| DET | Kendrick Law | WR | Knee - ACL | IR. Injured Reserve |
| DET | Payton Turner | DE | Back | IR. Injured Reserve |
| DET | Loren Strickland | SAF | Undisclosed | Questionable for Week 4 at Carolina |
| DET | Anthony Firkser | TE | Leg | Questionable for Week 4 at Carolina |
| DET | Ben Bartch | OT | Foot | Out for Week 4 at Carolina. Expected Return - Week 5 |
| GB | K. Randolph Jr. | DT | Undisclosed | Questionable for Week 4 at Tampa Bay |
| GB | T. Dean III | SAF | Undisclosed | Questionable for Week 4 at Tampa Bay |
| GB | McCallan Castles | TE | Undisclosed | Questionable for Week 4 at Tampa Bay |
| GB | Luke Lachey | TE | Foot | Questionable for Week 4 at Tampa Bay |
| GB | Luke Musgrave | TE | Neck | Physically Unable to Perform. Expected Return - Week 5 |
| GB | Zach Bako-Bewele | G | Knee | IR. Injured Reserve |
| GB | P. Strong Jr. | RB | Hamstring | Questionable for Week 4 at Tampa Bay |
| GB | Savion Williams | WR | Ankle | IR. Injured Reserve. Expected Return - Week 5 |
| GB | Johnathan Baldwin | SAF | Knee | IR. Injured Reserve |
| GB | Isaiah Dunn | CB | Undisclosed | Questionable for Week 4 at Tampa Bay |
| GB | Thomas Yassmin | TE | Undisclosed | IR. Injured Reserve |
| GB | Jordon Riley | DT | Achilles | Physically Unable to Perform. Expected Return - Week 5 |
| GB | Micah Parsons | LB | Knee - ACL | Physically Unable to Perform. Expected Return - Week 6 |
| GB | Marlon Jones | DB | Undisclosed | IR. Injured Reserve |
| GB | Jayden Reed | WR | Neck | IR. Injured Reserve |
| GB | Jager Burton | G | Groin | Limited Practice on Friday. Questionable for Week 4 at Tampa Bay |
| GB | RJ Maryland | TE | Hamstring | Questionable for Week 4 at Tampa Bay |
| GB | Collin Oliver | LB | Achilles | IR. Injured Reserve. Expected Return - Week 5 |
| GB | Jacob Monk | G | Quadriceps | Inactive for Week 4 at Tampa Bay |
| GB | Anthony Campbell | DT | Ankle | Inactive for Week 4 at Tampa Bay |
| GB | Aaron Banks | G | Toe | Inactive for Week 4 at Tampa Bay |
| GB | Warren Brinson | DT | Calf | IR. Injured Reserve. Expected Return - Week 8 |
| HOU | Azeez Al-Shaair | LB | Groin | Inactive for Week 4 vs. Dallas |
| HOU | Jake Hansen | LB | Knee | Full Practice on Friday. Questionable for Week 4 vs. Dallas |
| HOU | Irv Smith | TE | Ankle | Questionable for Week 4 vs. Dallas |
| HOU | Casey Toohill | DE | Personal | Retired |
| HOU | Sam Hagen | OT | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| HOU | Graham Mertz | QB | Knee - ACL | IR. Injured Reserve |
| HOU | Jake Hummel | LB | Groin | IR. Injured Reserve. Expected Return - Week 7 |
| HOU | Braden Smith | OT | Foot | IR. Injured Reserve. Expected Return - Week 5 |
| HOU | Joe Mixon | RB | Foot | Out for Week 4 vs. Dallas. Expected Return - Week 4 |
| HOU | Sione Takitaki | LB | Hamstring | Questionable for Week 4 vs. Dallas |
| HOU | Ed Ingram | G | Groin | Full Practice on Friday. Questionable for Week 4 vs. Dallas |
| HOU | Kurt Hinish | DT | Undisclosed | Questionable for Week 4 vs. Dallas |
| HOU | M.J. Stewart | SAF | Knee | Physically Unable to Perform. Expected Return - Week 5 |
| HOU | Jadeveon Clowney | DE | Knee | Did Not Practice on Friday. Questionable for Week 4 vs. Dallas |
| HOU | Jimmie Ward | CB | Foot | Questionable for Week 4 vs. Dallas |
| HOU | Tank Dell | WR | Knee - ACL + MCL | IR. Injured Reserve. Expected Return - Week 5 |
| HOU | Mario Edwards | DT | Knee - ACL | IR. Injured Reserve |
| HOU | Ja'Marcus Ingram | CB | Shoulder | IR. Injured Reserve. Expected Return - Week 5 |
| HOU | Jayden Higgins | WR | Knee - ACL | IR. Injured Reserve |
| HOU | DJ Turner | WR | Undisclosed | Questionable for Week 4 vs. Dallas |
| HOU | Trent Brown | OT | Illness | Full Practice on Friday. Questionable for Week 4 vs. Dallas |
| HOU | Logan Hall | DE | Knee | Limited Practice on Friday. Questionable for Week 4 vs. Dallas |
| HOU | Solomon Byrd | DE | Ankle | IR. Injured Reserve |
| HOU | Ali Gaye | DE | Knee | IR. Injured Reserve |
| HOU | To'oHenry To'oTo'o | LB | Shoulder | IR. Injured Reserve. Expected Return - Week 6 |
| HOU | Kyonte Hamilton | DT | Undisclosed | Questionable for Week 4 vs. Dallas |
| HOU | Kayden McDonald | DT | Ankle | IR. Injured Reserve. Expected Return - Week 5 |
| HOU | Dylan Horton | DE | Achilles | IR. Injured Reserve |
| HOU | British Brooks | RB | Hamstring | IR. Injured Reserve. Expected Return - Week 9 |
| HOU | E.J. Speed | LB | Quadriceps | Physically Unable to Perform |
| HOU | K.C. Ossai | LB | Undisclosed | IR. Injured Reserve |
| HOU | Noah Whittington | RB | Quadriceps | Out for Week 4 vs. Dallas. Expected Return - Week 9 |
| IND | Chris Lammons | DB | Foot | Questionable for Week 5 at Pittsburgh |
| IND | Alec Pierce | WR | Heel | IR. Injured Reserve. Expected Return - Week 7 |
| IND | D.J. Montgomery | WR | Abdomen | IR. Injured Reserve |
| IND | Micheal Clemons | DE | Toe | IR. Injured Reserve. Expected Return - Week 7 |
| IND | Jack Wilson | OT | Undisclosed | Questionable for Week 5 at Pittsburgh |
| IND | R. Lowery III | DB | Undisclosed | Retired |
| IND | Cameron Mitchell | DB | Undisclosed | IR. Injured Reserve |
| IND | Will Mallory | TE | Thumb | IR. Injured Reserve. Expected Return - Week 5 |
| IND | Sean McKeon | TE | Undisclosed | Questionable for Week 5 at Pittsburgh |
| IND | Mike Hilton | CB | Shoulder | Questionable for Week 5 at Pittsburgh |
| IND | Jacob Phillips | LB | Biceps | Questionable for Week 5 at Pittsburgh |
| IND | Carson Towt | TE | Undisclosed | IR. Injured Reserve |
| IND | Darius Slayton | WR | Coach's Decision | Inactive for Week 4 at Washington |
| IND | Keenan Allen | WR | Groin | Inactive for Week 4 at Washington |
| IND | Riley Leonard | QB | Coach's Decision | Inactive for Week 4 at Washington |
| IND | G. Gumbs Jr. | DE | Coach's Decision | Inactive for Week 4 at Washington |
| IND | DJ Giddens | RB | Coach's Decision | Inactive for Week 4 at Washington |
| IND | Dalton Tucker | G | Coach's Decision | Inactive for Week 4 at Washington |
| JAC | Jack Kiser | LB | Coach's Decision | — |
| JAC | Daniel Faalele | G | Coach's Decision | — |
| JAC | Montaric Brown | CB | Hamstring | Inactive for Week 4 at Cincinnati |
| JAC | Jalen Huskey | SAF | Coach's Decision | — |
| JAC | CJ Williams | WR | Coach's Decision | — |
| JAC | Wesley Williams | DE | Coach's Decision | — |
| JAC | Christian Braswell | CB | Knee | Inactive for Week 4 at Cincinnati |
| JAC | Parker Hughes | LB | Undisclosed | IR. Injured Reserve |
| JAC | Keith Taylor | CB | Undisclosed | Questionable for Week 4 at Cincinnati |
| JAC | Devon Marshall | DB | Undisclosed | Questionable for Week 4 at Cincinnati |
| JAC | Patrick Mekari | OT | Back | IR. Injured Reserve. Expected Return - Week 5 |
| JAC | GiorgioGarrett DiGiorgio | OT | Undisclosed | IR. Injured Reserve |
| JAC | Sam Mustipher | C | Undisclosed | IR. Injured Reserve |
| JAC | Zach Durfee | DE | Upper Body | IR. Injured Reserve. Expected Return - Week 5 |
| JAC | Dane Jackson | CB | Personal | Retired |
| JAC | Jared Bartlett | LB | Leg | IR. Injured Reserve |
| JAC | Trystan Colon-Castillo | C | Personal | Retired |
| JAC | B. Green II | DE | Elbow | IR. Injured Reserve. Expected Return - Week 6 |
| JAC | Carter Bradley | QB | Thumb | Questionable for Week 4 at Cincinnati |
| KC | Deon Bush | DB | Achilles | Questionable for Week 4 at Las Vegas |
| KC | Chris Oladokun | QB | Undisclosed | Questionable for Week 4 at Las Vegas |
| KC | Josh Simmons | OT | Back | Out for Week 4 at Las Vegas. Expected Return - Week 6 |
| KC | EJ Smith | RB | Undisclosed | Questionable for Week 4 at Las Vegas |
| KC | Jimmy Holiday | WR | Undisclosed | IR. Injured Reserve |
| KC | Jeff Caldwell | WR | Knee | IR. Injured Reserve |
| KC | John Michael Gyllenborg | TE | Knee | IR. Injured Reserve |
| KC | C.J. Hanson | G | Undisclosed | Questionable for Week 4 at Las Vegas |
| KC | Omarr Norman-Lott | DT | Knee - ACL | Physically Unable to Perform. Expected Return - Week 6 |
| KC | Matt Waletzko | OT | Undisclosed | IR. Injured Reserve |
| KC | Cooper McDonald | LB | Knee | IR. Injured Reserve. Expected Return - Week 7 |
| KC | Ethan Downs | LB | Knee - ACL | IR. Injured Reserve |
| LAC | Dalevon Campbell | WR | Leg | Questionable for Week 4 at Seattle |
| LAC | Sincere Brown | WR | Undisclosed | Questionable for Week 4 at Seattle |
| LAC | Donte Jackson | CB | Concussion | Full Practice on Friday. Questionable for Week 4 at Seattle |
| LAC | Trey Pipkins | OT | Knee | IR. Injured Reserve. Expected Return - Week 8 |
| LAC | Dez Fitzpatrick | WR | Undisclosed | Questionable for Week 4 at Seattle |
| LAC | Dalvin Tomlinson | DE | Hamstring | Out for Week 4 at Seattle. Expected Return - Week 5 |
| LAC | Brenen Thompson | WR | Quadriceps | Out for Week 4 at Seattle. Expected Return - Week 5 |
| LAC | Trey Lance | QB | Groin | Limited Practice on Friday. Questionable for Week 4 at Seattle |
| LAC | Scott Matlock | DT | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| LAC | Kayode Awosika | G | Lower Leg | Out for Week 4 at Seattle. Expected Return - Week 5 |
| LAC | Ladd McConkey | WR | Foot | Limited Practice on Friday. Questionable for Week 4 at Seattle |
| LAC | Denzel Perryman | MLB | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| LAC | Kyle Kennard | LB | Undisclosed | Questionable for Week 4 at Seattle |
| LAC | Mike Williams | WR | Undisclosed | Roster Exemption |
| LAC | Bradley Bozeman | C | Undisclosed | Retired |
| LAC | Charlie Kolar | TE | Forearm | Out for Week 4 at Seattle. Expected Return - Week 5 |
| LAC | David Njoku | TE | Lower Leg | IR. Injured Reserve. Expected Return - Week 8 |
| LAC | Will Dissly | TE | Undisclosed | Questionable for Week 4 at Seattle |
| LAC | Derwin James | FS | Hamstring | Questionable for Week 4 at Seattle |
| LAC | Luke Grimm | WR | Undisclosed | Questionable for Week 4 at Seattle |
| LAC | Branson Taylor | OT | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| LAC | Isaiah World | OT | Knee | NFI-R for Week 4 at Seattle |
| LAC | Elijah Molden | CB | Hamstring | Limited Practice on Friday. Questionable for Week 4 at Seattle |
| LAC | KeAndre Lambert-Smith | WR | Hamstring | IR. Injured Reserve. Expected Return - Week 6 |
| LAC | Tyler Biadasz | C | Knee | IR. Injured Reserve |
| LAR | Zech McPhearson | CB | Undisclosed | Questionable for Week 4 at Philadelphia |
| LAR | Colby Parkinson | TE | Shoulder - AC Joint | Did Not Practice on Friday. Questionable for Week 4 at Philadelphia |
| LAR | Ronnie Rivers | RB | Calf | IR. Injured Reserve. Expected Return - Week 7 |
| LAR | Anthony Torres | TE | Ankle | Questionable for Week 4 at Philadelphia |
| LAR | Myles Garrett | LB | Knee | IR. Injured Reserve. Expected Return - Week 6 |
| LAR | Keagen Trost | OT | Hamstring | IR. Injured Reserve. Expected Return - Week 5 |
| LAR | Jaylen Watson | CB | Shoulder | Out for Week 4 at Philadelphia. Expected Return - Week 5 |
| LAR | Daniel Rickert | LB | Knee | IR. Injured Reserve |
| LAR | Keir Thomas | LB | Groin | IR. Injured Reserve |
| LAR | Alex Johnson | DB | Undisclosed | Questionable for Week 4 at Philadelphia |
| LAR | Drey Norwood | CB | Undisclosed | Questionable for Week 4 at Philadelphia |
| LAR | Matthew Caldwell | QB | Undisclosed | IR. Injured Reserve |
| LAR | Mario Williams | WR | Undisclosed | Questionable for Week 4 at Philadelphia |
| LAR | Terrance Ferguson | TE | Ankle | IR. Injured Reserve. Expected Return - Week 8 |
| LAR | E. Walls III | LB | Undisclosed | IR. Injured Reserve |
| LAR | Darious Williams | DB | Undisclosed | Retired |
| LAR | Justin Dedich | OT | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| LAR | Josaiah Stewart | LB | Groin | Questionable for Week 4 at Philadelphia |
| LAR | Aaron Donald | DT | Back | Out for Week 4 at Philadelphia. Expected Return - Week 5 |
| LV | Jackson Powers-Johnson | G | Groin | Out for Week 4 vs. Kansas City. Expected Return - Week 5 |
| LV | Chase Roberts | WR | Undisclosed | Questionable for Week 4 vs. Kansas City |
| LV | D. Thornton Jr. | WR | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| LV | Justin Pickett | G | Undisclosed | IR. Injured Reserve |
| LV | Christian Wilkins | DT | Foot | Questionable for Week 4 vs. Kansas City |
| LV | Jack Bech | WR | Forearm | IR. Injured Reserve. Expected Return - Week 8 |
| LV | Raheem Mostert | RB | Knee | Questionable for Week 4 vs. Kansas City |
| LV | Chris Collier | RB | Undisclosed | IR. Injured Reserve |
| LV | Joshua Miles | OT | Undisclosed | Retired |
| LV | Corey Rucker | WR | Undisclosed | IR. Injured Reserve |
| LV | Chigozie Anusiem | DB | Knee | IR. Injured Reserve |
| LV | Keyron Crawford | DE | Ankle | IR. Injured Reserve |
| LV | Carter Runyon | TE | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| LV | Brennan Jackson | LB | Undisclosed | IR. Injured Reserve |
| MIA | Cole Turner | TE | Undisclosed | IR. Injured Reserve |
| MIA | Zane Gonzalez | K | Undisclosed | Questionable for Week 4 at Minnesota |
| MIA | Carter Warren | OT | Undisclosed | Questionable for Week 4 at Minnesota |
| MIA | Jamaree Salyer | G | Knee | Questionable for Week 4 at Minnesota |
| MIA | Caleb Douglas | WR | Ankle | Out for Week 4 at Minnesota. Expected Return - Week 5 |
| MIA | Omar Brown | DB | Undisclosed | Questionable for Week 4 at Minnesota |
| MIA | Ben Sims | TE | Undisclosed | Questionable for Week 4 at Minnesota |
| MIA | D. Baker Jr. | CB | Undisclosed | Physically Unable to Perform. Expected Return - Week 5 |
| MIA | De'Von Achane | RB | Knee - ACL | IR. Injured Reserve |
| MIA | Kenneth Grant | DT | Leg | IR. Injured Reserve. Expected Return - Week 5 |
| MIA | Storm Duck | CB | Knee | Physically Unable to Perform. Expected Return - Week 5 |
| MIA | Kyle Louis | LB | Knee | IR. Injured Reserve. Expected Return - Week 7 |
| MIA | Ethan Robinson | CB | Undisclosed | Questionable for Week 4 at Minnesota |
| MIA | Rene Konga | DE | Undisclosed | IR. Injured Reserve |
| MIA | Tyreek Hill | WR | Knee - ACL | Out for Week 4 at Minnesota. Expected Return - Week 7 |
| MIA | R. Harrison Jr. | LB | Hamstring | IR. Injured Reserve. Expected Return - Week 7 |
| MIA | Trey Moore | LB | Ankle | IR. Injured Reserve. Expected Return - Week 5 |
| MIA | Lonnie Johnson | SAF | Leg | Questionable for Week 4 at Minnesota |
| MIA | R. Beal Jr. | DE | Hamstring | Out for Week 4 at Minnesota. Expected Return - Week 5 |
| MIN | Luke Wysong | WR | Undisclosed | Questionable for Week 4 vs. Miami |
| MIN | Josh Oliver | TE | Biceps | IR. Injured Reserve |
| MIN | Justin Jefferson | WR | Ankle | Out for Week 4 vs. Miami. Expected Return - Week 5 |
| MIN | Tyreek Chappell | CB | Undisclosed | IR. Injured Reserve |
| MIN | Jaylon Hutchings | DE | Undisclosed | Questionable for Week 4 vs. Miami |
| MIN | Michael Jurgens | G | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| MIN | Jordan Mason | RB | Thumb | IR. Injured Reserve. Expected Return - Week 7 |
| MIN | Bryson Nesbit | TE | Undisclosed | Questionable for Week 4 vs. Miami |
| MIN | Ben Yurosek | TE | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| MIN | Jeff Okudah | CB | Concussion | Questionable for Week 4 vs. Miami |
| MIN | Kejon Owens | RB | Illness | Questionable for Week 4 vs. Miami |
| MIN | Matt Nelson | OT | Undisclosed | Questionable for Week 4 vs. Miami |
| MIN | Tyler Batty | LB | Knee - ACL | IR. Injured Reserve |
| MIN | Brett Thorson | P | Hamstring | Out for Week 4 vs. Miami. Expected Return - Week 5 |
| MIN | Marcus Allen | DB | Undisclosed | Questionable for Week 4 vs. Miami |
| MIN | Jamal Adams | LB | Quadriceps | IR. Injured Reserve |
| MIN | Nick Samac | C | Knee | IR. Injured Reserve. Expected Return - Week 8 |
| MIN | Charles Demmings | CB | Hamstring | Out for Week 4 vs. Miami. Expected Return - Week 5 |
| MIN | Jermar Jefferson | RB | Undisclosed | Questionable for Week 4 vs. Miami |
| MIN | Taki Taimani | DL | Undisclosed | Questionable for Week 4 vs. Miami |
| MIN | C.J. Ham | FB | Undisclosed | Retired |
| NE | Christian Gonzalez | CB | Shoulder | Out for Week 4 at Buffalo. Expected Return - Week 5 |
| NE | A.J. Brown | WR | Ankle | IR. Injured Reserve. Expected Return - Week 8 |
| NE | Reggie Gilliam | RB | Knee | Limited Practice on Friday. Questionable for Week 4 at Buffalo |
| NE | Craig Woodson | SAF | Shoulder | Limited Practice on Friday. Questionable for Week 4 at Buffalo |
| NE | Bryce Baringer | P | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| NE | Myles Montgomery | RB | Undisclosed | IR. Injured Reserve |
| NE | Isaiah Iton | DE | Undisclosed | Questionable for Week 4 at Buffalo |
| NE | Eli Raridon | TE | Thigh | Limited Practice on Friday. Questionable for Week 4 at Buffalo |
| NE | Marcus Bryant | OT | Ankle | IR. Injured Reserve. Expected Return - Week 5 |
| NE | Khalil Jacobs | LB | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| NE | Quintayvious Hutchins | LB | Knee | IR. Injured Reserve. Expected Return - Week 7 |
| NE | Greg Van Roten | G | Thigh | IR. Injured Reserve. Expected Return - Week 8 |
| NE | Brenden Schooler | SAF | Back | NFI-R for Week 4 at Buffalo |
| NE | Dre'Mont Jones | LB | Shoulder | Limited Practice on Friday. Questionable for Week 4 at Buffalo |
| NE | Eric Butler | SAF | Undisclosed | Questionable for Week 4 at Buffalo |
| NE | Morgan Moses | OT | Foot | Limited Practice on Friday. Questionable for Week 4 at Buffalo |
| NE | Shane Zylstra | TE | Undisclosed | Questionable for Week 4 at Buffalo |
| NE | Julian Hill | TE | Knee | IR. Injured Reserve |
| NE | Mike Onwenu | G | Ankle | IR. Injured Reserve. Expected Return - Week 7 |
| NE | Andrew Rupcich | G | Undisclosed | Questionable for Week 4 at Buffalo |
| NE | H. Landry III | LB | Undisclosed | Physically Unable to Perform. Expected Return - Week 5 |
| NE | Jeremiah Webb | WR | Arm | IR. Injured Reserve |
| NE | Jimmy Kibble | WR | Undisclosed | Questionable for Week 4 at Buffalo |
| NE | Christian Elliss | LB | Chest | Limited Practice on Friday. Questionable for Week 4 at Buffalo |
| NE | Dell Pettus | SAF | Ankle | IR. Injured Reserve. Expected Return - Week 7 |
| NE | Christian Barmore | DT | Shoulder | Inactive for Week 4 at Buffalo |
| NE | Channing Canada | CB | Hamstring | Inactive for Week 4 at Buffalo |
| NE | Tanner Arkin | TE | Coach's Decision | Inactive for Week 4 at Buffalo |
| NO | Pete Werner | LB | Shoulder | Did Not Practice on Saturday. Questionable for Week 4 vs. Atlanta |
| NO | Carl Granderson | DE | Ankle | Out for Week 4 vs. Atlanta. Expected Return - Week 5 |
| NO | Anfernee Jennings | LB | Knee | Out for Week 4 vs. Atlanta. Expected Return - Week 5 |
| NO | Jordyn Tyson | WR | Hamstring | IR. Injured Reserve. Expected Return - Week 5 |
| NO | Kaden Elliss | LB | Calf | Out for Week 4 vs. Atlanta. Expected Return - Week 5 |
| NO | L. Styles Jr. | SAF | Calf | IR. Injured Reserve. Expected Return - Week 5 |
| NO | Ja'Lynn Polk | WR | Undisclosed | Retired |
| NO | Bryan Bresee | DT | Knee - ACL | IR. Injured Reserve |
| NO | Zach Wood | LS | Calf | IR. Injured Reserve. Expected Return - Week 6 |
| NO | Keeshawn Silver | DT | Undisclosed | Questionable for Week 4 vs. Atlanta |
| NO | Damien Alford | WR | Undisclosed | Questionable for Week 4 vs. Atlanta |
| NO | Travis Etienne | RB | Hamstring | IR. Injured Reserve. Expected Return - Week 9 |
| NO | Barry Wesley | OT | Undisclosed | Questionable for Week 4 vs. Atlanta |
| NO | Nick Saldiveri | G | Knee | Physically Unable to Perform |
| NO | Mason Tipton | WR | Leg | Physically Unable to Perform. Expected Return - Week 5 |
| NO | Rejzohn Wright | DB | Hip | IR. Injured Reserve |
| NO | Dillon Radunz | OT | Knee - ACL | IR. Injured Reserve |
| NO | David Long | DB | Undisclosed | IR. Injured Reserve |
| NO | Noah Fant | TE | Abdomen | Limited Practice on Saturday. Questionable for Week 4 vs. Atlanta |
| NO | Ty Chandler | RB | Knee | IR. Injured Reserve |
| NO | Dalys Beanum | CB | Undisclosed | Questionable for Week 4 vs. Atlanta |
| NO | K. Banks Jr. | OT | Ankle | IR. Injured Reserve. Expected Return - Week 12 |
| NO | Derek Carr | QB | Undisclosed | Retired |
| NO | Jaylan Ford | LB | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| NO | Moliki Matavao | TE | Knee | IR. Injured Reserve |
| NYG | Jarrick Bernard-Converse | CB | Knee | IR. Injured Reserve |
| NYG | Dante Miller | RB | Groin | Questionable for Week 4 vs. Arizona |
| NYG | C. Austin III | WR | Knee | IR. Injured Reserve |
| NYG | Gunner Olszewski | WR | Achilles | IR. Injured Reserve |
| NYG | Rico Payton | CB | Undisclosed | IR. Injured Reserve |
| NYG | Korie Black | CB | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| NYG | Paulson Adebo | CB | Knee | IR. Injured Reserve. Expected Return - Week 6 |
| NYG | Thaddeus Dixon | CB | Achilles | IR. Injured Reserve |
| NYG | Ben Sauls | K | Undisclosed | Questionable for Week 4 vs. Arizona |
| NYG | D.J. James | CB | Undisclosed | Questionable for Week 4 vs. Arizona |
| NYG | Roy Robertson-Harris | DE | Achilles | IR. Injured Reserve |
| NYG | Jaxson Dart | QB | Knee - Meniscus | IR. Injured Reserve |
| NYG | Sam Roberts | DT | Undisclosed | Questionable for Week 4 vs. Arizona |
| NYG | Brian Burns | LB | Knee - ACL | IR. Injured Reserve |
| NYJ | Caullin Lacy | WR | Undisclosed | Questionable for Week 4 at Chicago |
| NYJ | Mason Taylor | TE | Thumb | Out for Week 4 at Chicago. Expected Return - Week 5 |
| NYJ | Tim Patrick | WR | Groin | IR. Injured Reserve. Expected Return - Week 5 |
| NYJ | Breece Hall | RB | Quadriceps | Out for Week 4 at Chicago. Expected Return - Week 5 |
| NYJ | Chip Trayanum | RB | Neck | IR. Injured Reserve |
| NYJ | Dominic Richardson | RB | Undisclosed | Questionable for Week 4 at Chicago |
| NYJ | Tyler Baron | DE | Knee | Physically Unable to Perform. Expected Return - Week 5 |
| NYJ | Connor Hulstein | TE | Undisclosed | Questionable for Week 4 at Chicago |
| NYJ | O. Cooper Jr. | WR | Ankle | IR. Injured Reserve. Expected Return - Week 6 |
| NYJ | Adonai Mitchell | WR | Finger | Out for Week 4 at Chicago. Expected Return - Week 5 |
| NYJ | Francisco Mauigoa | LB | Quadriceps | Out for Week 4 at Chicago. Expected Return - Week 5 |
| NYJ | VJ Payne | SAF | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| NYJ | Marcelino McCrary-Ball | LB | Ankle | IR. Injured Reserve. Expected Return - Week 7 |
| NYJ | Christopher Smith | S | Undisclosed | Questionable for Week 4 at Chicago |
| NYJ | DT Sheffield | WR | Undisclosed | Questionable for Week 4 at Chicago |
| NYJ | Keilan Robinson | RB | Undisclosed | Questionable for Week 4 at Chicago |
| NYJ | Anez Cooper | G | Shoulder | IR. Injured Reserve. Expected Return - Week 5 |
| NYJ | David Onyemata | DT | Groin | IR. Injured Reserve. Expected Return - Week 9 |
| NYJ | Kingsley Enagbare | LB | Knee | Limited Practice on Friday. Questionable for Week 4 at Chicago |
| NYJ | G. Scott Jr. | WR | Undisclosed | Questionable for Week 4 at Chicago |
| NYJ | Dylan Parham | G | Knee | Out for Week 4 at Chicago. Expected Return - Week 5 |
| NYJ | Chase Curtis | TE | Knee | Questionable for Week 4 at Chicago |
| NYJ | Tre Brown | CB | Finger | IR. Injured Reserve |
| NYJ | Kingsley Jonathan | DE | Thigh | IR. Injured Reserve |
| NYJ | Arian Smith | WR | Knee - ACL | IR. Injured Reserve |
| PHI | Landon Dickerson | G | Knee | IR. Injured Reserve. Expected Return - Week 6 |
| PHI | Tariq Castro-Fields | CB | Heel | Questionable for Week 4 vs. L.A. Rams |
| PHI | Tucker Large | S | Undisclosed | NFI-R for Week 4 vs. L.A. Rams |
| PHI | Chance Campbell | LB | Undisclosed | Out for Week 4 vs. L.A. Rams. Expected Return - Week 8 |
| PHI | Jakorian Bennett | DB | Knee | IR. Injured Reserve. Expected Return - Week 5 |
| PHI | Danny Gray | WR | Undisclosed | Questionable for Week 4 vs. L.A. Rams |
| PHI | Johnny Wilson | WR | Knee | IR. Injured Reserve |
| PHI | DeVonta Smith | WR | Hamstring | Out for Week 4 vs. L.A. Rams. Expected Return - Week 5 |
| PHI | Marcus Epps | SAF | Groin | Out for Week 4 vs. L.A. Rams. Expected Return - Week 5 |
| PHI | Andre' Sam | SAF | Foot | IR. Injured Reserve |
| PHI | Ja'Quinden Jackson | RB | Undisclosed | Questionable for Week 4 vs. L.A. Rams |
| PHI | Fred Johnson | OT | Knee | Out for Week 4 vs. L.A. Rams. Expected Return - Week 5 |
| PHI | Eli Stowers | TE | Hamstring | IR. Injured Reserve. Expected Return - Week 5 |
| PHI | Elijah Mitchell | RB | Undisclosed | Questionable for Week 4 vs. L.A. Rams |
| PHI | Dallas Goedert | TE | Knee - MCL | Out for Week 4 vs. L.A. Rams. Expected Return - Week 5 |
| PHI | Grant Calcaterra | TE | Back | IR. Injured Reserve. Expected Return - Week 5 |
| PHI | Zack Baun | LB | Concussion | Inactive for Week 4 vs. L.A. Rams |
| PHI | Marquise Brown | WR | Ankle | Inactive for Week 4 vs. L.A. Rams |
| PHI | Lane Johnson | OT | Personal | Questionable for Week 4 vs. L.A. Rams |
| PIT | Derrick Harmon | DT | Foot | Doubtful for Week 5 vs. Indianapolis |
| PIT | Jamel Dean | CB | Ankle | Doubtful for Week 5 vs. Indianapolis |
| PIT | Max Hurleman | RB | Undisclosed | Out for Week 5 vs. Indianapolis. Expected Return - Week 6 |
| PIT | Robert Woods | WR | Undisclosed | Retired |
| PIT | Gennings Dunker | G | Knee | IR. Injured Reserve. Expected Return - Week 7 |
| PIT | Donte Kent | CB | Undisclosed | Physically Unable to Perform. Expected Return - Week 5 |
| PIT | Cory Trice | CB | Knee | Questionable for Week 5 vs. Indianapolis |
| PIT | Logan Lee | DT | Undisclosed | IR. Injured Reserve |
| PIT | Israel Mukuamu | SAF | Undisclosed | Questionable for Week 5 vs. Indianapolis |
| PIT | Jacob Slade | DL | Undisclosed | Questionable for Week 5 vs. Indianapolis |
| PIT | Daequan Hardy | CB | Undisclosed | IR. Injured Reserve |
| PIT | Lorenzo Thompson | OT | Undisclosed | Questionable for Week 5 vs. Indianapolis |
| PIT | Adam Thielen | WR | Undisclosed | Retired |
| PIT | Montana Lemonious-Craig | WR | Lower Body | Questionable for Week 5 vs. Indianapolis |
| PIT | DeShon Elliott | SAF | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| PIT | Jack Driscoll | OT | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| PIT | Cole Burgess | WR | Undisclosed | IR. Injured Reserve |
| PIT | Eli Heidenreich | RB | Coach's Decision | Inactive for Week 4 at Cleveland |
| PIT | Gabriel Rubio | DE | Coach's Decision | Inactive for Week 4 at Cleveland |
| PIT | Drew Allar | QB | Coach's Decision | Inactive for Week 4 at Cleveland |
| PIT | K. Jobity Jr. | DT | Coach's Decision | Inactive for Week 4 at Cleveland |
| PIT | Will Howard | QB | Coach's Decision | Inactive for Week 4 at Cleveland |
| PIT | Rico Dowdle | RB | Toe | Inactive for Week 4 at Cleveland |
| SEA | Jadarian Price | RB | Chest | IR. Injured Reserve. Expected Return - Week 8 |
| SEA | Ty Okada | SAF | Hamstring | Full Practice on Friday. Questionable for Week 4 vs. L.A. Chargers |
| SEA | Zach Charbonnet | RB | Knee - ACL | Physically Unable to Perform. Expected Return - Week 5 |
| SEA | Bud Clark | SAF | Ankle | IR. Injured Reserve |
| SEA | Mason Richman | G | Leg | IR. Injured Reserve |
| SEA | Anthony Bradford | G | Knee | IR. Injured Reserve. Expected Return - Week 7 |
| SEA | Tyrone Broden | CB | Undisclosed | Questionable for Week 4 vs. L.A. Chargers |
| SEA | Joseph Vaughn | LB | Undisclosed | Questionable for Week 4 vs. L.A. Chargers |
| SEA | Ja'Markis Weston | LB | Undisclosed | Questionable for Week 4 vs. L.A. Chargers |
| SEA | Chazz Surratt | LB | Calf | Limited Practice on Friday. Questionable for Week 4 vs. L.A. Chargers |
| SEA | Irvin Charles | WR | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| SEA | Robbie Ouzts | RB | Neck | IR. Injured Reserve |
| SEA | Shane Lemieux | OG | Undisclosed | Questionable for Week 4 vs. L.A. Chargers |
| SEA | Terrion Arnold | CB | Personal | Commissioner's exempt list for Week 4 vs. L.A. Chargers. Expected Return - Week 5 |
| SEA | Power Echols | LB | Undisclosed | Questionable for Week 4 vs. L.A. Chargers |
| SEA | Aaron Smith | LB | Undisclosed | Questionable for Week 4 vs. L.A. Chargers |
| SEA | Shemar Jean-Charles | CB | Undisclosed | Questionable for Week 4 vs. L.A. Chargers |
| SEA | Johnathan Hankins | DT | Back | Questionable for Week 4 vs. L.A. Chargers |
| SEA | Jake Bobo | WR | Knee | IR. Injured Reserve |
| SEA | Harrison Bryant | TE | Undisclosed | Questionable for Week 4 vs. L.A. Chargers |
| SF | Nick Zakelj | OT | Undisclosed | IR. Injured Reserve |
| SF | Sam Okuayinonu | DT | Foot | IR. Injured Reserve. Expected Return - Week 15 |
| SF | Austen Pleasants | OL | Knee | IR. Injured Reserve. Expected Return - Week 5 |
| SF | Nate Hobbs | CB | Groin | IR. Injured Reserve. Expected Return - Week 5 |
| SF | Patrick Taylor | RB | Undisclosed | Questionable for Week 4 vs. Denver |
| SF | Nick Bosa | DE | Calf | Out for Week 4 vs. Denver. Expected Return - Week 5 |
| SF | Nick Martin | LB | Hamstring | IR. Injured Reserve. Expected Return - Week 5 |
| SF | Mykel Williams | DE | Knee - ACL | Physically Unable to Perform. Expected Return - Week 5 |
| SF | Jake Tonges | TE | Knee - MCL | IR. Injured Reserve |
| SF | Isaac Guerendo | RB | Pectoral | Physically Unable to Perform. Expected Return - Week 5 |
| SF | Dre Greenlaw | LB | Quadriceps | Limited Practice on Friday. Questionable for Week 4 vs. Denver |
| SF | Alfred Collins | DT | Knee | IR. Injured Reserve |
| SF | Mikail Kamara | DE | Knee | IR. Injured Reserve |
| SF | De'Zhaun Stribling | WR | Ankle | IR. Injured Reserve. Expected Return - Week 11 |
| SF | Darrick Forrest | SAF | Undisclosed | IR. Injured Reserve |
| SF | Demarcus Robinson | WR | Ankle | IR. Injured Reserve. Expected Return - Week 7 |
| SF | Titus Leo | DE | Undisclosed | Questionable for Week 4 vs. Denver |
| SF | CJ West | DT | Undisclosed | IR. Injured Reserve. Expected Return - Week 7 |
| SF | K.J. Henry | DE | Undisclosed | Questionable for Week 4 vs. Denver |
| SF | Brandon Aiyuk | WR | Personal | Did Not Report |
| SF | Tanner McLachlan | TE | Undisclosed | Questionable for Week 4 vs. Denver |
| SF | Jaden Dugger | LB | Shoulder | Limited Practice on Friday. Questionable for Week 4 vs. Denver |
| SF | Brett Toth | G | Concussion | IR. Injured Reserve |
| SF | Isaiah Prince | OT | Knee | Questionable for Week 4 vs. Denver |
| SF | Christian Kirk | WR | Calf | IR. Injured Reserve. Expected Return - Week 5 |
| SF | Andrew Farmer | DE | Back | IR. Injured Reserve |
| SF | J. Thompson Jr. | DT | Ankle | Out for Week 4 vs. Denver. Expected Return - Week 5 |
| SF | Mike Evans | WR | Ribs | Limited Practice on Friday. Questionable for Week 4 vs. Denver |
| SF | Keion White | DE | Hamstring | Limited Practice on Friday. Questionable for Week 4 vs. Denver |
| SF | Ricky Pearsall | WR | Knee - PCL | IR. Injured Reserve |
| TB | Baker Mayfield | QB | Thumb | Out for Week 4 vs. Green Bay. Expected Return - Week 7 |
| TB | Josh Hayes | DB | Knee | IR. Injured Reserve. Expected Return - Week 5 |
| TB | Chase Lucas | CB | Undisclosed | Questionable for Week 4 vs. Green Bay |
| TB | SirVocea Dennis | LB | Calf | Limited Practice on Friday. Questionable for Week 4 vs. Green Bay |
| TB | Jalen McMillan | WR | Knee - PCL | IR. Injured Reserve. Expected Return - Week 11 |
| TB | Marcus Banks | DB | Undisclosed | Questionable for Week 4 vs. Green Bay |
| TB | Kadarius Calloway | RB | Undisclosed | Questionable for Week 4 vs. Green Bay |
| TB | Kemon Hall | DB | Undisclosed | Questionable for Week 4 vs. Green Bay |
| TB | Mohamed Kamara | LB | Knee | IR. Injured Reserve |
| TB | Benjamin Morrison | CB | Quadriceps | Out for Week 4 vs. Green Bay. Expected Return - Week 6 |
| TB | Dennis Houston | WR | Groin | Questionable for Week 4 vs. Green Bay |
| TB | Ko Kieft | TE | Elbow | Out for Week 4 vs. Green Bay. Expected Return - Week 6 |
| TB | Damarion Williams | CB | Undisclosed | Questionable for Week 4 vs. Green Bay |
| TB | Xavier Williams | SAF | Hip | Questionable for Week 4 vs. Green Bay |
| TB | Deshawn McKnight | DT | Hamstring | Questionable for Week 4 vs. Green Bay |
| TB | Rakeem Nunez-Roches | DT | Ankle | Full Practice on Friday. Questionable for Week 4 vs. Green Bay |
| TB | David Sills | WR | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| TB | DJ Williams | RB | Undisclosed | Questionable for Week 4 vs. Green Bay |
| TB | Ja'Qurious Conley | SAF | Undisclosed | Questionable for Week 4 vs. Green Bay |
| TB | Jacob Parrish | CB | Personal | Limited Practice on Friday. Questionable for Week 4 vs. Green Bay |
| TB | R. Bain Jr. | LB | Groin | Inactive for Week 4 vs. Green Bay |
| TB | DeMonte Capehart | DT | Coach's Decision | — |
| TEN | Jackie Marshall | DT | Coach's Decision | — |
| TEN | Brandon Crenshaw-Dickson | OT | Coach's Decision | — |
| TEN | Kylen Granson | TE | Coach's Decision | — |
| TEN | Michael Carter | RB | Coach's Decision | — |
| TEN | Jaylon Jones | DB | Coach's Decision | — |
| TEN | Garrett Dellinger | G | Illness | Questionable for Week 4 at Baltimore |
| TEN | Jalyn Armour-Davis | CB | Achilles | Questionable for Week 4 at Baltimore |
| TEN | Jaren Kanak | TE | Pectoral | IR. Injured Reserve |
| TEN | Kendell Brooks | SAF | Undisclosed | IR. Injured Reserve |
| TEN | Joshua Williams | CB | Pectoral | IR. Injured Reserve. Expected Return - Week 5 |
| TEN | Fernando Carmona | G | Ankle | IR. Injured Reserve. Expected Return - Week 8 |
| TEN | Jaylen Harrell | DE | Knee - ACL | IR. Injured Reserve |
| TEN | Dorian Mausi | LB | Undisclosed | IR. Injured Reserve. Expected Return - Week 5 |
| TEN | Sean Brown | LB | Undisclosed | Questionable for Week 4 at Baltimore |
| TEN | S. Banks Jr. | LB | Undisclosed | Questionable for Week 4 at Baltimore |
| TEN | Milo Eifler | LB | Undisclosed | IR. Injured Reserve |
| TEN | Dominique Hampton | LB | Undisclosed | Questionable for Week 4 at Baltimore |
| TEN | Tanoh Kpassagnon | DE | Undisclosed | IR. Injured Reserve |
| TEN | Justin Hardee | DB | Undisclosed | Questionable for Week 4 at Baltimore |
| TEN | Jackson Slater | G | Foot | IR. Injured Reserve. Expected Return - Week 8 |
| TEN | K. Winston Jr. | SAF | Shoulder | Did Not Practice on Friday. Questionable for Week 4 at Baltimore |
| TEN | Tyjae Spears | RB | Ankle | Full Practice on Friday. Questionable for Week 4 at Baltimore |
| TEN | Nazeeh Johnson | CB | Ankle | Questionable for Week 4 at Baltimore |
| WAS | D.J. Davidson | DT | Undisclosed | Retired |
| WAS | Ahkello Witherspoon | CB | Personal | Retired |
| WAS | Jordan Magee | LB | Hamstring | IR. Injured Reserve. Expected Return - Week 6 |
| WAS | River Cracraft | WR | Undisclosed | Questionable for Week 5 vs. N.Y. Giants |
| WAS | Quentin Moore | TE | Undisclosed | Questionable for Week 5 vs. N.Y. Giants |
| WAS | Tyler Cooper | G | Undisclosed | Questionable for Week 5 vs. N.Y. Giants |
| WAS | Jacoby Jones | WR | Undisclosed | Questionable for Week 5 vs. N.Y. Giants |
| WAS | Johnny Newton | DT | Pectoral | IR. Injured Reserve. Expected Return - Week 11 |
| WAS | Laremy Tunsil | OT | Triceps | IR. Injured Reserve. Expected Return - Week 15 |
| WAS | Leo Chenal | LB | Neck | IR. Injured Reserve |
| WAS | Nick Bellore | LB | Personal | Retired |
| WAS | D. Wise Jr. | DE | Quadriceps | Physically Unable to Perform. Expected Return - Week 5 |
| WAS | Curtis Jacobs | LB | Undisclosed | Questionable for Week 5 vs. N.Y. Giants |
| WAS | Jeremy McNichols | RB | Quadriceps | IR. Injured Reserve. Expected Return - Week 5 |
| WAS | Trey Amos | CB | Ankle | IR. Injured Reserve. Expected Return - Week 5 |
| WAS | M. Jones Jr. | LB | Undisclosed | Questionable for Week 5 vs. N.Y. Giants |
| WAS | Samuel Cosmi | OT | Concussion | Inactive for Week 4 vs. Indianapolis |
| WAS | Luke McCaffrey | WR | Coach's Decision | Inactive for Week 4 vs. Indianapolis |
| WAS | Terry McLaurin | WR | Hamstring | Inactive for Week 4 vs. Indianapolis |
| WAS | Charles Omenihu | DE | Groin | Questionable for Week 5 vs. N.Y. Giants |
| WAS | Rachaad White | RB | Shoulder | Inactive for Week 4 vs. Indianapolis |
| WAS | Javontae Jean-Baptiste | LB | Coach's Decision | Inactive for Week 4 vs. Indianapolis |
| WAS | Nick Cross | SAF | Illness | Inactive for Week 4 vs. Indianapolis |
| WAS | Jaylin Lane | WR | Leg | Questionable for Week 5 vs. N.Y. Giants |
| WAS | Jayden Daniels | QB | Elbow | Inactive for Week 4 vs. Indianapolis |
| WAS | Marcus Mariota | QB | Knee | Out for Week 5 vs. N.Y. Giants. Expected Return - Week 5 |
Philadelphia Eagles vs. Los Angeles Rams: NFC East Hosts NFC West in Week 4 Clash at Lincoln Financial Field
Cleveland Browns vs. Pittsburgh Steelers — Week 4 AFC North Divisional Showdown