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Game Preview: Arizona Cardinals at Dallas Cowboys

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Game Details:

  • Matchup: Arizona Cardinals at Dallas Cowboys
  • Date: Monday, November 3
  • Time: 8:15 PM EST
  • Spread: Cowboys -3.5
  • Total: 53.5

Game Preview

The national spotlight turns to a Monday night clash as the Dallas Cowboys host the Arizona Cardinals in a game where the biggest storyline is the lengthy injury report for both squads. The Cowboys enter as slim 3.5-point home favorites, but their ability to cover may depend on who is healthy enough to take the field.

The Cowboys’ injury situation has been described as looking “like a CVS receipt.” The offensive line, in particular, has been decimated. According to one report from earlier in the season, the team was down four offensive linemen from its opening-day roster, exposing a “lack of quality depth.” This unit’s health will be paramount against the Cardinals’ defensive front. The defense hasn’t escaped unscathed either, with linebacker Jack Sanborn recently being ruled out of a contest.

The visiting Cardinals are dealing with their own significant injury concerns. An October injury report listed quarterback Kyler Murray (foot) and defensive lineman Darius Robinson (pectoral) as not participating in practice, while wide receiver Zay Jones (knee) was also DNP. The Cardinals have already felt the sting of major injuries this season, having previously placed cornerback Starling Thomas V on season-ending IR with a torn ACL. The health of Murray, even if he plays, will be a critical factor in Arizona’s ability to pull off the road upset.

Prediction

This game is a classic case of a high betting total clashing with a mountain of injuries. The over/under is set at a lofty 53.5, suggesting a shootout is expected. However, the injury reports tell a different story.

The Cowboys’ offensive line is in shambles, which will make it incredibly difficult to sustain drives and protect their quarterback. For Arizona, a less-than-100% Kyler Murray could limit the explosiveness of their offense. While both defenses have vulnerabilities that could lead to points, the offensive injuries are too significant to ignore. The under seems like the more logical play.

Regarding the spread, giving points with a team as banged-up as the Cowboys is a risky proposition, even at home. Their depleted offensive line is a major liability. The Cardinals have the firepower to keep this game tight, and if their key players are active, they have a strong chance to not only cover the spread but win the game outright.

Prediction: Cardinals 27, Cowboys 23

The Pick: Cardinals +3.5

The Total: Under 53.5

Sources:
Cardinals Injury Report I Arizona Cardinals – AZCardinals.com
Arizona Cardinals Injury Status – ESPN
Indianapolis Colts injury report Week 6, Arizona Cardinals injury report
Packers-Cardinals Injury Report | Oct. 16, 2025
Arizona Cardinals Injury Report released : r/AZCardinals
Three Out, Surprise Questionable on Final Packers-Cardinals Injury …
Arizona Cardinals injury report: Weaver, Reiman banged up before …
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Commanders-Cardinals injury report
Arizona Cardinals Injury Report and Status 2025-26 – CBS Sports

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