An NFC West rivalry is renewed as the Seattle Seahawks travel to State Farm Stadium to take on the Arizona Cardinals. Divisional games are always hard-fought, and with a razor-thin point spread, this matchup is expected to be a nail-biter from start to finish.
Game Information:
- Matchup: Seattle Seahawks (Away) at Arizona Cardinals (Home)
- Game Date: Thursday, September 25
- Time: 8:16 PM EST
Betting Odds:
- Point Spread: Seahawks -1.5
- Total (Over/Under): 43.5
The Seahawks enter as slight road favorites, indicating that oddsmakers view this as nearly a toss-up. The low total of 43.5 points suggests a defensive battle or a game where offenses struggle to find their rhythm.
Team Breakdowns
Seattle Seahawks
The Seahawks come into this divisional clash looking to assert their presence on the road. The offense’s effectiveness will likely hinge on the health of its key players. Running back Kenneth Walker Jr. has been on injury reports recently with an oblique issue, and his ability to handle a full workload will be a critical factor in Seattle’s game plan.
Defensively, Seattle will look to capitalize on an injury-depleted Cardinals offense. With a secondary that aims to be opportunistic, they will be tasked with containing Arizona’s passing attack, which is now the clear focal point for the home team. As indicated by the official team injury reports, Seattle will need all hands on deck to secure a crucial divisional road win.
Arizona Cardinals
The Cardinals head into this game facing a monumental challenge. The team was dealt a devastating blow with the news that star running back James Conner is out for the season with a foot injury. This loss fundamentally changes the identity of the Arizona offense, removing a reliable workhorse and team leader from the backfield.
The pressure now shifts squarely to the shoulders of quarterback Kyler Murray and the passing game. However, that unit is also banged up. Recent reports show wide receiver Zay Jones is in the concussion protocol, making his status for Monday night uncertain. Without Conner to balance the offense, the Seahawks’ pass rush can be more aggressive, and their secondary can focus on blanketing Arizona’s receivers. The Cardinals will need their backup running backs and the offensive line to step up in a massive way to avoid becoming one-dimensional.
Prediction
This game will be defined by one piece of news: the absence of James Conner. His injury is a game-changer that tilts the field heavily in Seattle’s favor. While divisional games are notoriously unpredictable and the Cardinals are playing at home, the loss of their offensive engine is too significant to overcome on short notice.
The Seahawks’ defense can now zero in on stopping a predictable, pass-heavy Arizona offense. Expect Seattle to control the clock with its own run game and do just enough to leave Arizona with a win. The low point total seems prescient, as the Cardinals’ offense will likely struggle to score without its top weapon.
Final Score Prediction: Seahawks 23, Cardinals 17
- The Pick: Seattle Seahawks -1.5
- Total: Under 43.5
Sources:
Seahawks Injury Report | Seattle Seahawks – seahawks.com
Seattle Seahawks Injury Status – ESPN
Seahawks Injury Report : r/detroitlions
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Seattle Seahawks Injury Report and Status 2025-26 – CBSSports.com
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