MLB Game Preview and Pick: Pirates at Orioles

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A September showdown is on tap in Baltimore as the Orioles host the Pittsburgh Pirates in an interleague matchup. The home team enters as a considerable favorite, looking to capitalize on their home-field advantage.

Game Details:

  • Matchup: Pittsburgh Pirates (Road) at Baltimore Orioles (Home)
  • Date: Tuesday, September 9, 2025
  • Time: 6:35 PM EST
  • Venue: Oriole Park at Camden Yards, Baltimore, MD
  • Starting Pitchers: Mike Burrows (RHP) for the Pirates vs. Kyle Bradish (RHP) for the Orioles
  • Moneyline Odds: Pirates +128 | Orioles -157

Pittsburgh Pirates Preview

The Pirates hit the road as underdogs, looking to play spoiler in Baltimore. They’ll send right-hander Mike Burrows to the mound to face a potent Orioles lineup. For Pittsburgh to pull off the upset, Burrows will need to effectively manage the game early and keep the Orioles’ bats quiet, allowing his offense a chance to build a lead. The Pirates have navigated the usual bumps and bruises of a long season and will need a complete team effort to overcome the odds in a tough road environment.

Baltimore Orioles Preview

The Baltimore Orioles are favored for a reason, especially on their home turf. With Kyle Bradish taking the ball, the O’s have a reliable starter capable of setting the tone. Bradish will look to attack a Pirates lineup that can be inconsistent, trusting his defense and the supportive atmosphere at Camden Yards. Like all teams in September, the Orioles have managed their share of injuries throughout the season but remain a formidable opponent as they continue their campaign. Expect the Orioles to try and jump on the visiting Pirates early and let their starter settle into a rhythm.

Prediction

While there’s always value in a road underdog, the edge in this matchup clearly goes to Baltimore. The Orioles are the stronger team on paper, playing at home, and have the more established starter in Kyle Bradish on the mound. The moneyline of -157 reflects the confidence the oddsmakers have in Baltimore to handle their business.

The key will be the Orioles’ offense against Mike Burrows. If they can put up runs in the early innings, it will be a steep uphill climb for the Pirates. Look for Baltimore to secure the win, backed by a solid start from Bradish and timely hitting.

The Pick: Baltimore Orioles (-157)

Predicted Score: Orioles 6 – Pirates 3

Sources:
Pittsburgh Pirates Injury Status – ESPN
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2025 Pittsburgh Pirates Injuries – MLB – CBSSports.com
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2025 Pittsburgh Pirates Injury Report | RosterResource | FanGraphs …
Pirates injury report: Colin Moran, Phillip Evans close to getting back …
2024-2025 Pittsburgh Pirates Injury Report | Lines.com
Pirates Injury Update: Spencer Horwitz, Bryan Reynolds, Jared Jones

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