Giants at Padres Game Odds and Prediction August 21, 2025 4:10 PM EST

Matchup: San Francisco Giants (61-66) at San Diego Padres (71-56)

Location: Petco Park, San Diego, CA

Starting Pitchers: Justin Verlander (RHP) vs. Dylan Cease (RHP)

Moneyline Odds: Giants +158, Padres -194

Preview:

This National League West matchup features a compelling pitching duel between veteran Justin Verlander of the Giants and young ace Dylan Cease of the Padres. The Padres, currently holding a Wild Card spot, will look to continue their strong play against a Giants team battling to stay in the playoff picture.

The Giants’ offense has been inconsistent this season, and they will face a tough challenge against Cease, who has been a reliable presence in the Padres’ rotation. Verlander, on the other hand, brings a wealth of experience to the mound and will need to keep the Padres’ potent lineup in check. The Giants’ success will hinge on their ability to manufacture runs and Verlander’s ability to limit damage.

The Padres, fueled by a strong offense and solid pitching, will be looking to take advantage of their home-field advantage. Cease needs to be effective early, setting the tone for the game.

Prediction:

This game is likely to be a closely contested affair. However, the Padres, with their superior record, home-field advantage, and the reliable Dylan Cease on the mound, have a slight edge.

Pick: Padres (-194) – While the odds aren’t great, San Diego is the stronger team in a more advantageous position.