Game Details:
- Matchup: Carolina Panthers at San Francisco 49ers
- Date: Monday, November 24
- Time: 8:15 PM EST
- Location: Levi’s Stadium, Santa Clara, CA
- TV: ESPN
- Betting Line: 49ers -7.5, Over/Under 49.5
Monday Night Football Showdown in Santa Clara
Week 12 of the NFL season concludes with a primetime NFC battle as the Carolina Panthers travel to face the San Francisco 49ers. The 49ers enter the Monday Night Football contest as heavy 7.5-point home favorites, with oddsmakers expecting a fairly high-scoring affair with a point total set at 49.5.
Can the Panthers Pull Off the Upset?
The Carolina Panthers face a significant challenge on the road against a formidable opponent. As the clear underdogs, their path to victory will require a nearly flawless performance. While specific details on their recent form are limited in the provided information, their official injury report page has been updated through Week 12, indicating their health will be a critical factor heading into this matchup. To cover the spread or win outright, the Panthers will need to control the pace of the game and exploit any weaknesses in the San Francisco defense.
49ers Look to Defend Home Turf Despite Injuries
The San Francisco 49ers are looking to secure a key conference win at Levi’s Stadium. However, they will be doing so with a slightly depleted linebacker corps. According to the team’s final injury report released on November 22, linebacker Dee Bethune has been ruled OUT for the game against the Panthers. Furthermore, fellow linebacker Demetrius Flannigan-Gifford is listed as Questionable.
While the 49ers’ core offensive and defensive stars appear ready to go, these injuries will test the team’s defensive depth. The Panthers will likely try to attack the middle of the field to take advantage of these absences.
Prediction
The 49ers are favored by more than a touchdown for a reason. They are at home, playing in primetime, and possess one of the league’s most talented rosters. While the linebacker injuries are a legitimate concern and could help the Panthers keep the game competitive, the 49ers’ offensive firepower, led by quarterback Brock Purdy, should be enough to overcome it.
The 7.5-point spread is a significant hurdle, but San Francisco has the explosive capability to pull away in the second half. The point total of 49.5 suggests that points are expected, and with the 49ers’ potent offense and slightly weakened defense, this game has the potential to turn into a shootout. Expect San Francisco to ultimately secure the win and cover the spread in a game that lives up to its offensive billing.
Final Score Prediction: 49ers 31, Panthers 20
Sources:
Panthers Injury Report | Carolina Panthers – Panthers.com
Carolina Panthers Injury Status – ESPN
Packers – Panthers Injury Report : r/GreenBayPackers
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Carolina Panthers Injury Report and Status 2025-26 – CBS Sports
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