Game Details:
- Matchup: Indianapolis Colts (Away) at Kansas City Chiefs (Home)
- Date: Sunday, November 23
- Time: 1:00 PM EST
- Venue: Arrowhead Stadium, Kansas City, MO
- Broadcast: CBS/Paramount+
- Betting Line: Chiefs -3.5
- Over/Under: 50.5
Game Preview
The Indianapolis Colts travel to the notoriously loud Arrowhead Stadium for a critical Week 12 showdown against the Kansas City Chiefs. While the Chiefs enter as 3.5-point favorites at home, history suggests this may not be a straightforward affair. The Colts have had surprising success against the Chiefs, winning 14 of their last 19 meetings. However, recent betting trends tell a different story, with Indianapolis going just 1-5 against the spread in their last six games against Kansas City.
The biggest storyline for the visiting Colts revolves around the health of their starting quarterback, Daniel Jones. Jones was a late addition to the injury report this week, listed as limited in practice with a calf injury. A less-than-100% quarterback heading into one of the league’s toughest road environments could spell trouble for the Indianapolis offense. The good news for the Colts is that they are expected to get “massive help on defense” for this Week 12 matchup, a much-needed boost as they prepare to face Patrick Mahomes and the formidable Chiefs offense.
The Chiefs, meanwhile, look to maintain their dominance in the AFC. While their core offensive stars like Mahomes and Travis Kelce remain durable, the team isn’t entirely without concerns. Rookie offensive tackle Kingsley Suamataia is listed as questionable for the game after being in the concussion protocol, a potential weak spot the Colts’ pass rush could look to exploit.
Prediction & Pick
This game’s outcome likely hinges on the effectiveness of Colts quarterback Daniel Jones. Even if he plays, his limited mobility against a creative Chiefs defense at Arrowhead is a major concern. The Colts’ defense may be getting reinforcements, which could help them keep the game closer than expected and challenge the high 50.5-point total.
However, it’s difficult to bet against Patrick Mahomes at home, especially when he’s only favored by just over a field goal. While the Colts have a strong historical track record in this series, the current quarterback situation is too significant to ignore. The Chiefs should be able to capitalize on a potentially limited Colts offense and secure a victory by at least a touchdown. With the Colts’ defensive boost and their quarterback’s injury, the total may stay just under the line.
The Pick: Kansas City Chiefs -3.5
Predicted Score: Chiefs 27, Colts 20
Sources:
Colts Injury Report | Indianapolis Colts – colts.com
Los Angeles Chargers Indianapolis Colts Injury Report Week 7 2025
Indianapolis Colts Injury Status – ESPN
Tennessee Titans vs Indianapolis Colts injury report: Josh Downs …
Indianapolis Colts Injury Report and Status 2025-26 – CBS Sports
Colts vs. Titans injury report
Indianapolis Colts Get Near-Clean Injury Report for Titans Matchup
Colts injury report: Josh Downs, Nick Cross, other starters return
Indianapolis Colts Injury Report: QB1 Is Limited | Stampede Blue
Texans vs. Colts Injury Report – Week 8, 2024 | FOX Sports