Game Details:
- Matchup: USC Trojans at Oregon Ducks
- Date: Saturday, November 22
- Time: 3:30 PM EST
- Venue: Autzen Stadium, Eugene, OR
- Opening Line: Oregon -10.5, Over/Under 59.5
Big Ten Showdown in Eugene as Trojans Visit Ducks
A high-stakes, late-season Big Ten battle is on deck as the USC Trojans travel to the notoriously loud Autzen Stadium to take on the Oregon Ducks. With the conference championship picture coming into focus, this matchup carries significant weight for both programs. Oregon enters as a formidable 10.5-point home favorite, with oddsmakers expecting a fair number of points in a game with a total set at 59.5.
Can the Trojans Weather the Storm?
USC’s season has been a test of resilience, particularly when it comes to player health. Throughout the 2025 campaign, the Trojans have seen key players land on the weekly availability reports. Earlier in the season, question marks surrounded offensive linemen against Nebraska and wide receiver Prince Strachan was listed as “out” for the Georgia Southern game. The Trojans’ success often hinges on their offensive firepower, and their ability to protect the quarterback and give him time to find his weapons will be paramount against a physical Oregon front.
To keep this game close and pull off the upset, USC must be at or near full strength. As per Big Ten policy, the official injury report will be released just two hours before kickoff, and all eyes will be on the status of USC’s key contributors on both sides of the ball.
Ducks Battling Injuries but Remain a Force
The Oregon Ducks have navigated their own significant injury challenges this season to remain a conference contender. The wide receiver room has been particularly hard-hit, with a previous report noting that Kyler Kasper was out for the season, while fellow wideouts Evan Stewart and Gary Bryant have also appeared on injury lists. The health of the offense has been a consistent storyline, with the Ducks often having to rely on their depth.
Despite these hurdles, being a double-digit favorite at this stage of the season speaks volumes about the talent and coaching in Eugene. The Ducks’ defense will be tasked with containing USC’s offense in a game that could determine their path to the Big Ten title game. The return of players like cornerback Jahlil Florence, who was working his way back from a leg injury late in the 2024 season, highlights the program’s “next man up” mentality and ability to reload.
Prediction
This game will likely be decided by which team’s stars are healthiest and which team’s depth can make the biggest impact. The 10.5-point spread is a large number for a rivalry between two talented Big Ten programs. Oregon’s home-field advantage at Autzen is one of the best in college football and is certainly factored into that line.
However, USC has the offensive identity to score and keep pace. While Oregon has proven its mettle all season, the Trojans have the talent to keep this game within a single score. The injury concerns for Oregon’s receivers could limit their explosiveness just enough for USC’s defense to get a few key stops.
The total of 59.5 feels high for a late-November conference game where both teams have dealt with offensive injuries and the defensive intensity will be at a peak. Expect a hard-fought, physical contest that stays just under the total.
The Pick: USC +10.5
Over/Under: Under 59.5
Predicted Score: Oregon 31, USC 24
Sources:
USC Injury Report: Trojans out and questionable against Nebraska …
OU vs USC Injury Report – 10/16/24 : r/oklahomafootball
USC Injury Report: Trojans out and questionable against Georgia …
USC Trojans Injuries 2025-2026 – Updated NCAAF Injury Report
The LSU Football vs. USC Injury Report: Chris Hilton’s Status …
USC Injury Report: Josh Fatu In Doubt With Ankle Injury (11/15)
Big Ten releases full Michigan–USC injury report for Week 7
USC Injury Report: Car accident sidelines Josh Fatu (10/17)
USC Injury Report: Trojans out and questionable against Iowa
USC Injury Report: Steven Mitchell Out For Season With ACL Tear