NFL Game Preview & Prediction: Atlanta Falcons vs. Indianapolis Colts

Game Details

Matchup: Atlanta Falcons (3-5) at Indianapolis Colts
Date: Sunday, November 9, 2025
Time: 9:30 a.m. EST
Location: Olympic Stadium, Berlin, Germany
TV: NFL Network
Betting Odds: Colts -6.5, Over/Under 48.5

Berlin Showdown: Depleted Colts and Falcons Meet in International Clash

The NFL’s international series heads to Berlin, Germany, for an early morning kickoff between the Atlanta Falcons and the Indianapolis Colts. While the Colts are designated as the home team and enter as 6.5-point favorites, this matchup is defined more by who won’t be on the field than who will. Both teams are navigating significant injuries to star players, particularly on the defensive side of the ball, turning this Week 10 game into a battle of attrition.

Can the Falcons Offense Exploit a Weakened Front?

The Falcons limp into Germany with a 3-5 record, desperate for a win to keep their season afloat. Their hopes of pressuring the Colts’ offense took a massive hit this week, as reports confirm that premier edge rusher Leonard Floyd will be out with a hamstring injury. Floyd’s absence cripples a pass rush that already struggles with consistency. Compounding their issues is the season-long loss of starting offensive tackle Kaleb McGary, who is on Injured Reserve.

Despite these setbacks, Atlanta has a golden opportunity. The Colts’ defense is in even worse shape. If the Falcons’ patchwork offensive line can give its quarterback time, there should be plays to be made against a severely depleted Indianapolis defensive front.

Colts Face Major Test on Defense

The Colts may be the favorites, but their biggest strength has been compromised. According to the latest injury reports, Indianapolis will be without three key defensive linemen for the game in Berlin. This catastrophic loss up front will make it incredibly difficult for the Colts to generate a pass rush or contain the Falcons’ rushing attack.

On offense, the Colts have had their own injury scares, with star receiver Michael Pittman Jr. appearing on the injury report earlier in the week. While his status seems more optimistic, the team’s ability to put up points will be crucial to offset its defensive deficiencies. The pressure will be on their offense to build an early lead and force the Falcons into obvious passing situations.

Prediction

This game will be decided in the trenches, where both teams are a shell of their full-strength selves. The Colts are giving 6.5 points on a neutral field, a spread that feels too large given their massive injuries along the defensive line. The Falcons’ offense should be able to move the ball and score enough to keep this contest close.

Meanwhile, the absence of Leonard Floyd for Atlanta and the multiple missing linemen for Indianapolis suggests that both quarterbacks will have more time in the pocket than usual. This points to a high-scoring affair where both defenses struggle to get stops. The over/under of 48.5 seems very attainable.

While the Colts may have enough offensive firepower to eke out a victory, covering the spread with a decimated defense is a tall order.

Final Score Prediction: Colts 28, Falcons 24