A classic ACC rivalry with conference title implications is set to take center stage as the Florida State Seminoles travel to Death Valley to take on the Clemson Tigers. In what is expected to be a tightly contested battle, this Saturday night showdown could hinge on which team is healthier down the home stretch of the season.
Game Details:
- Matchup: Florida State Seminoles at Clemson Tigers
- Date: Saturday, November 8, 2025
- Time: 7:00 PM EST
- Location: Clemson Memorial Stadium, Clemson, SC
- Point Spread: Clemson -1.5
- Total: 56.5
Florida State Seminoles Outlook
The Seminoles enter this crucial Week 11 matchup with some lingering questions on their official injury report. According to reports released this week, the running back room is banged up, with both Kam Davis and Roydell Williams listed as “Probable” for the game against Clemson. While “Probable” suggests they are likely to play, their effectiveness could be a storyline to watch. An unnamed linebacker is also listed as “Questionable.”
This isn’t the first time key FSU players have appeared on the injury report this season. Quarterback Tommy Castellanos was previously listed as “probable” ahead of a game against Virginia, and Williams himself was a game-time decision earlier in the year against Stanford. While the Seminoles have managed these situations before, facing a tough Clemson defense on the road with a potentially limited backfield presents a significant challenge.
Clemson Tigers Outlook
The news is more optimistic for the Clemson Tigers, who are playing at home and appear to be getting healthy at the right time. According to a Greenville News report for the FSU game, Clemson is expected to have “key contributors available” for this pivotal ACC contest. This is a massive boost for a team that has dealt with its own share of injuries throughout the 2025 season.
Earlier in the year, the Tigers saw key players like wide receiver Antonio Williams and safety Khalil Barnes return from injuries. More recently, in an October game against SMU, star quarterback Cade Klubnik was listed as “questionable,” highlighting the injury bug the team has had to navigate. With the ACC now requiring teams to release public injury reports, the positive update ahead of their biggest home game of the season suggests the Tigers will be at or near full strength. Playing in a hostile Death Valley environment at night gives the Tigers a distinct advantage, especially in a game with such a narrow point spread.
Prediction
The betting line for this game, with Clemson favored by just 1.5 points, essentially makes this a pick’em, giving the home team a slight nod. The deciding factor looks to be team health.
While Florida State’s key running backs are expected to play, nagging injuries can limit a player’s burst and durability over four quarters. On the other sideline, Clemson is reporting positive news, with key players expected to be available. In a matchup this close, being the healthier team is a monumental advantage. Combined with the raucous environment of a night game in Death Valley, the scales tip in favor of the Tigers.
The total of 56.5 points suggests oddsmakers expect a fair amount of scoring, and with both offenses having potent weapons, this game has the potential to be a back-and-forth affair. However, the combination of Clemson’s improving health and home-field advantage should be just enough to secure a critical conference victory.
The Pick: Clemson -1.5
Over/Under: Over 56.5
Predicted Score: Clemson 31, Florida State 27
Sources:
Florida State Seminoles Injuries 2025-2026 – Updated NCAAF Injury …
FSU vs. Stanford: Multiple Seminoles removed from updated injury …
FSU football vs Virginia injury report: Tommy Castellanos is probable
Florida State announces initial injury report ahead of Clemson clash …
Mississippi State football vs Florida injury report for Week 8
NCAAF Injuries Report for the Florida State Seminoles | Oddstrader
LSU football injury report includes Maason Smith vs. Florida State
SEC Student-Athlete Availability Report: Football – Southeastern …
Clemson, Florida State injury report for college football Week 11
Florida State football has released its final injury report ahead of …