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NHL Game Preview: Ottawa Senators at Boston Bruins

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Game Details:

  • Matchup: Ottawa Senators vs. Boston Bruins
  • Date: Thursday, November 6, 2025
  • Time: 7:00 PM EST
  • Venue: TD Garden, Boston, MA

Odds:

  • Ottawa Senators: -128 (Moneyline)
  • Boston Bruins: +106 (Moneyline)

Preview

The Ottawa Senators travel to Boston to take on a Bruins team that is struggling with significant injuries on their blue line. The Senators enter this Atlantic Division matchup as road favorites, a testament to both their own strong play and the depleted state of their opponent.

The Bruins are facing a major challenge on defense. The team is still without star defenseman Charlie McAvoy, who was lost for the season back in April 2025. Compounding that loss, fellow defensemen Hampus Lindholm (lower body) is considered week-to-week, and Jordan Harris was placed on injured reserve in late October, sidelining him for two months. Facing “one of the Eastern Conference’s most” formidable opponents in Ottawa without three key pieces of their defensive corps will be a monumental task for Boston.

While the Bruins are usually a dominant force on home ice, their injury woes have made them a rare home underdog. The Senators, meanwhile, appear to be relatively healthy and will look to exploit Boston’s battered defense. The moneyline reflects this reality, with oddsmakers giving a clear edge to the visiting team.

Prediction

The story of this game is injuries. It’s difficult to see the Bruins’ defense, missing McAvoy, Lindholm, and Harris, being able to contain the Senators’ attack. Boston’s resilience will be tested, but the personnel losses are too significant to overcome against a quality opponent.

The Senators are road favorites for a reason. Expect them to control the pace of play and capitalize on the defensive mismatches. While the Bruins will put up a fight in front of their home crowd, the talent gap on the blue line will be the deciding factor.

The Pick: Ottawa Senators (-128)

Sources:
Ottawa Senators Injury Status – ESPN
Ottawa Senators Injury Report and Status 2025-26 – CBS Sports
Kirill Kaprizov Injury Status – Wild vs. Senators Injury Report Decemb…
Predators vs. Senators Injury Report Today – February 3
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