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NHL Game Preview: Detroit Red Wings at Buffalo Sabres

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Game: Detroit Red Wings vs. Buffalo Sabres

Date: Tuesday, October 22

Time: 7:40 PM EST

Venue: KeyBank Center, Buffalo, NY

An Atlantic Division rivalry is renewed as the Detroit Red Wings travel to Buffalo to take on the Sabres in what promises to be a tightly contested matchup. Both young, aspiring teams are looking to make a statement early in the season and climb the divisional ladder.

Betting Odds

The oddsmakers see this game as a virtual toss-up, highlighting the expected competitive nature of the contest.

  • Detroit Red Wings: -106
  • Buffalo Sabres: -113

The odds give a slight edge to the hometown Sabres, but this is essentially a pick’em game, suggesting that a single play or a hot goaltender could be the difference-maker.

Detroit Red Wings Preview

The Red Wings enter this matchup with ambitions of building on their recent progress and finally breaking through into the playoff picture. While specific, up-to-the-minute injury information for this game is limited based on available search results, a late September report indicated that defenseman Simon Edvinsson was nearing a return, while forward James van Riemsdyk remained sidelined. Bettors and fans should monitor their official status closer to puck drop.

Detroit’s success hinges on its blend of dynamic young talent and veteran leadership. The offensive firepower of players like Dylan Larkin and Alex DeBrincat, combined with the skill of Lucas Raymond and the defensive prowess of Moritz Seider, makes them a threat on any given night. Their performance in Buffalo will depend on their ability to establish a forecheck and stay disciplined against a fast Sabres squad.

Buffalo Sabres Preview

The Sabres are looking to leverage their high-octane offense and home-ice advantage. Buffalo received some positive news in mid-October, as winger Zach Benson was reported to be back at practice, a good sign for his potential availability. The search results also note that top goaltending prospect Devon Levi was with the AHL’s Rochester Americans as of October 17, suggesting that Ukko-Pekka Luukkonen will likely be the man in the crease.

Buffalo’s core is built around a nucleus of exciting young stars like Tage Thompson, Rasmus Dahlin, and Dylan Cozens. Their game is predicated on speed and offensive creativity, which can overwhelm opponents. Playing in front of their home crowd, expect the Sabres to come out with energy and push the pace from the opening faceoff.

Prediction

This game profiles as a fast-paced, back-and-forth affair between two teams desperate to prove they belong in the Eastern Conference’s elite. The betting odds reflect just how close this matchup is.

While the Red Wings have the depth and structure to win on the road, the Sabres’ home-ice advantage cannot be discounted. In a game this evenly matched, the slight edge goes to the home team. Buffalo’s top-end offensive talent should be able to capitalize on their chances and feed off the energy at KeyBank Center.

Prediction: Sabres 4, Red Wings 3

Sources:
Detroit Red Wings Injury Status – ESPN
Detroit Red Wings Injury Report and Status 2025-26 – CBS Sports
Predators vs. Red Wings Injury Report Today – October 12 …
Predators vs. Red Wings Injury Report Today – October 12 | Daily …
Kirill Kaprizov Injury Status – Wild vs. Red Wings Injury Report …
Predators vs. Red Wings Injury Report Today – October 19
Predators vs. Red Wings Injury Report Today – October 12
Predators vs. Red Wings Injury Report Today – October 12
Detroit Red Wings Injury Status – ESPN (AU)
Red Wings Injury Update: Edvinsson Nearing Return, JVR Remains …

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