Week 3 of the 2024 NFL regular season is on the immediate horizon, and it should be a fun one. Primetime games will be riddled with big-name quarterbacks: Aaron Rodgers of the New York Jets on Thursday night, Patrick Mahomes of the Kansas City Chiefs on Sunday night and Josh Allen of the Buffalo Bills on Monday night. 

Make sure you check out our NFL predictions as we add our picks on the side and total for every game throughout the week – and throughout the entire season. Also make sure to check out our NFL best bets page for our top picks. For now, let’s break down the NFL Week 1 opening lines and give our best early bet to make.  

NFL Week 3 opening lines and odds 

Odds available at DraftKings Sportsbook at time of publishing.  

New England Patriots +6.5 (-105) vs New York Jets -6.5 (-115) – Thursday Night Football  

New York Giants +7 (-110) vs Cleveland Browns -7 (-110)  

Philadelphia Eagles -2.5 (-118) vs New Orleans Saints +2.5 (-102)  

Houston Texans -3 (+100) vs Minnesota Vikings +3 (-120)  

Denver Broncos +7 (-110) vs Tampa Bay Buccaneers -7 (-110)   

Los Angeles Chargers +2.5 (-110) vs Pittsburgh Steelers -2.5 (-110) 

Chicago Bears +1 (-110) vs Indianapolis Colts -1 (-110)  

Green Bay Packers +1.5 (-108) vs Tennessee Titans -1.5 (-112) 

Carolina Panthers +7 (-110) vs Las Vegas Raiders -7 (-110)  

Miami Dolphins +6.5 (-110) vs Seattle Seahawks -6.5 (-110)  

Detroit Lions -3.5 (-105) vs Arizona Cardinals +3.5 (-115) 

San Francisco 49ers -7 (-110) vs Los Angeles Rams +7 (-110)

Baltimore Ravens +1 (-115) vs Dallas Cowboys -1 (-105) 

Kansas City Chiefs -4.5 (-115) vs Atlanta Falcons +4.5 (-105) — Sunday Night Football  

Jacksonville Jaguars +5 (-108) vs Buffalo Bills -5 (-112) — Monday Night Football

Washington Commanders +7.5 (-110) vs Cincinnati Bengals -7.5 (-110) — Monday Night Football 

Best bet for NFL Week 3: Tampa Bay Buccaneers -7 over Denver Broncos (-110) 

Is the NFC South actually good this season? Carolina is obviously the worst team in the league and the jury is still out on Atlanta, but Tampa Bay and New Orleans are looking like the real deal.

The Bucs opened with a 37-20 blowout of Washington and then went into Detroit to pull off a 20-16 upset. Baker Mayfield has thrown for 474 yards with 5 touchdowns and 1 interception while also scoring once on the ground. Next up for Tampa Bay is a Denver team that is 0-2 and has produced just 1 touchdown through 2 games. It managed only 6 points against Pittsburgh in Week 2. Expecting the Broncos to stay within a touchdown on the road seems like a borderline absurd idea.

Although I would probably play this a couple of points higher, it would be wise to jump on it now while it’s still on the key number of 7. After all, let’s be honest, it’s probably going to move in Tampa Bay’s direction. 

We’ll have NFL Week 3 picks for every game!