We are now well into December and the playoff ramifications are ramping up in the NFL. Week 15 of the 2024 season is on the immediate horizon, and – needless to say – it’s a big one. Among the headliners are Rams vs 49ers, Dolphins vs Texans, Bills vs Lions and Packers vs Seahawks followed by a Monday Night Football double-header.
Make sure you check out our NFL predictions as we add our picks on the side and total for every game throughout the week – and throughout the entire season. Also make sure to check out our NFL best bets page for our top picks. For now, let’s break down the NFL Week 15 opening lines and give our best early bet to make.
NFL Week 15 opening lines and odds
Odds available at DraftKings Sportsbook at time of publishing
Los Angeles Rams +2.5 (-110) vs San Francisco 49ers -2.5 (-110) – Thursday Night Football
Kansas City Chiefs OFF (OFF) vs Cleveland Browns OFF (-OFF)
Cincinnati Bengals -5.5 (-110) vs Tennessee Titans +5.5 (-110)
Washington Commanders +5.5 (-110) vs New Orleans Saints -5.5 (-110)
Baltimore Ravens -5 (-110) vs New York Giants +5 (-110)
Dallas Cowboys +1 (-110) vs Carolina Panthers -1 (-110)
New York Jets -3.5 (-105) vs Jacksonville Jaguars +3.5 (-115)
Miami Dolphins +2 (-110) vs Houston Texans -2 (-110)
Indianapolis Colts +4 (-110) vs Denver Broncos –4 (-110)
Buffalo Bills +3 (-120) vs Detroit Lions -3 (+100)
Pittsburgh Steelers +4 (-110) vs Philadelphia Eagles -4 (-110)
New England Patriots +6.5 (-110) vs Arizona Cardinals -6.5 (-110)
Tampa Bay Buccaneers OFF (OFF) vs Los Angeles Chargers OFF (OFF)
Green Bay Packers -3 (+100) vs Seattle Seahawks +3 (-120) — Sunday Night Football
Chicago Bears +7 (-110) vs Minnesota Vikings -7 (-110) — Monday Night Football
Atlanta Falcons -4.5 (-110) vs Las Vegas Raiders +4.5 (-110) — Monday Night Football
Best bet for NFL Week 15: Houston Texans -2 over Miami Dolphins (-110)
The Jaguars were an easy best bet winner for me in my Week 14 opening lines article and I’m going right back to the well in the AFC South – this time with the Texans. Houston should be in a good spot for this upcoming weekend’s date with Miami. Head coach Demeco Ryans’ squad is coming off a bye and has the benefit of playing at home, while the Dolphins needed overtime to get past the Jets on Sunday and now have to go on the road.
Even with Tua Tagovailoa healthy, it’s hard to have much faith in the Fins. They are 6-7 overall, including 2-4 on the road. Their road setbacks have come by 3, 6, 13 and 21 points. Miami has not played particularly of late, either, as a blowout loss at Green Bay in Week 13 was followed by a less than impressive nail-biter against the Jets. Since November 11 the Dolphins have not defeated anyone other than the Raiders and Patriots. There is no reason to think they will take down the Texans.